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US 9,410,122 B2Granted
Treatment of limb ischemia
AssigneeReneuron Limited
InventorsJohn Sinden, Erik Miljan, Paolo Madeddu
Life of this patent
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Abstract
The present invention uses neural stem cells in the manufacture of a medicament for the treatment of a patient suffering peripheral arterial disease. The invention is particularly suited for treating limb ischemia or Buerger's disease.
Claims17
A method for treating peripheral arterial disease in a patient, comprising administering a therapeutic dose of neural stem cells to the patient;
- wherein, prior to administration, the neural stem cells are (i) suspended in a composition that comprises Trolox, Na+, K+, Ca2+, mg2+, Cl−, H2PO4−, HEPES, lactobionate, sucrose, mannitol, glucose, dextran-40, adenosine and glutathione and does not include a dipolar aprotic solvent, (ii) preserved at cryothermic temperatures below −20° C., and (iii) thawed;
- and
- wherein the cells are administered directly to the patient following thawing without any further processing steps.
A method for treating peripheral arterial disease in a patient, comprising
- (i) suspending neural stem cells in a composition comprising Trolox, Na+, K+, Ca2+, mg2+, Cl−, H2PO4−, HEPES, lactobionate, sucrose, mannitol, glucose, dextran-40, adenosine, and glutathione and does not include a dipolar aprotic solvent;
- (ii) preserving the suspended neural stem cells at cryothermic temperatures below −20° C.;
- (iii) thawing the stored or preserved neural stem cells;
- and
- (iv) administering the thawed neural stem cells directly to the patient following thawing without any further processing steps.
2 more elements
Dependencies are inferred from the claim text.