Drug-fluorophore complex for specific detection of tumor cells
AssigneeKorea Institute of Science and Technology
InventorsKwang Meyung Kim, Ick Chan Kwon, Sang Yoon Kim, Ju Hee Ryu, Eun Sung Jun, In San Kim
Life of this patent
Estimating the term…
Abstract
Disclosed is a drug-fluorophore complex for specific detection of tumor cells. Specifically, the drug-fluorophore complex includes a tumor cell-targeting drug penetrating tumor cells and non-tumor cells at different rates or levels, and a fluorescent substance chemically bonded to the tumor cell-targeting drug. The drug-fluorophore complex enables specific imaging of tumor cells only with high accuracy in a very simple manner without causing cytotoxicity.
Claims3
A drug-fluorophore complex for specific detection, via in vivo imaging, of tumor cells at a tumor cell site during surgery, the drug-fluorophore complex comprising:
- a tumor cell-targeting drug penetrating tumor cells and non-tumor cells at different rates or levels;
- and
- a fluorescent substance chemically bonded to the tumor cell-targeting drug, wherein the drug-fluorophore complex is applied to the tumor cell site during surgery whereby tumor cells are detected via in vivo imaging in an efficient manner without causing cytotoxicity during surgery,
- wherein the drug-fluorophore complex is any one of the compounds represented by Formulae 1 to 5:
Dependencies are inferred from the claim text.