Compounds and compositions for use in augmentation of glucose

A compound of formula (II):

• wherein
• X1, X2, X3 and X4 are each independently selected from the group consisting of S, O, CH2, CHR3, NH and NR3;
• provided that at least one of X1 to X4 is O or S and at least one of X1 to X4 is CHR3;
• V1, V2, V3 and V4 are each independently selected from N, C, CH and CR4;
• Y and Z are each S;
• R1 and R2 are each independently selected from straight or branched C1-C20 alkyl, straight or branched C2-C20 alkenyl and straight or branched C2-C20 alkynyl, each optionally interrupted with at least one NH;
• or wherein R1 and R2 together with Y, Z and the carbon atom connecting them form a 5 to 10 membered ring;
• optionally substituted by at least one group selected from straight or branched C1-C10 alkyl, straight or branched C2-C10 alkenyl and straight or branched C2-C10 alkynyl;
• R4 is selected from the group consisting of halogen, straight or branched C1-C20 alkyl, straight or branched C2-C20 alkenyl and straight or branched C2-C20 alkynyl;
• R3 is selected from the group consisting of straight or branched C1-C12 alkyl, straight or branched C2-C5 alkenyl, straight or branched C2-C5 alkynyl, —COOH, C1-C8 alkoxy, C1-C5 amidyle, C1-C5 carboxyl, C6-C12 aryl, C4-C12 heteroaryl and heterocyclyl, wherein each of aryl, heteroaryl and heterocyclyl is optionally substituted by at least one of alkoxy, alkyl, alkenyl, alkynyl, amino, cyano, halogen, and 1,3-dithian-benzyl.