# US 9,409,038 B2 · Apparatus for loading dosimetrically customizable brachytherapy carriers

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- Number: US 9,409,038 B2
- Document ID: US9409038B2
- Status: Granted
- Kind: B2
- Application number: 14/605,272
- Filed: 2015-01-26
- Published: 2015-07-16
- Granted: 2016-08-09
- Earliest claimed: 2011-04-28
- Assignees: GammaTile LLC
- Applicants: Gammatile LLC
- Inventors: Peter Nakaji; David Brachman; Heyoung McBride; Emad Youssef; Theresa Thomas
- Web page: https://patentgrep.com/patent/US9409038B2

## CPC

- A61N 5/1014: {Intracavitary radiation therapy}
- A61N 5/1007: {Arrangements or means for the introduction of sources into the body}
- A61N 5/1027: {Interstitial radiation therapy}
- A61N 5/103: {Treatment planning systems}
- A61N 2005/1009: {Apparatus for loading seeds into magazines or needles}
- A61N 2005/101: {Magazines or cartridges for seeds}
- A61N 2005/1023: {Means for creating a row of seeds, e.g. spacers}
- A61N 2005/1024: {Seeds}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present invention relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.

## Claims

### Claim 1

A treatment system comprising:
a radionuclide tile carrier having a first longitudinally planar surface, an opposing second longitudinally planar surface parallel to the first planar surface, and a uniform thickness therebetween;
a cylindrical radionuclide seed;
a guide tool; and
a loading device having:
a first planar surface facing and parallel to a second planar surface,
a third planar surface defining a loading bed perpendicular to the first and the second planar surfaces of the loading device, the loading bed between a first portion of the first planar surface of the loading device and a second portion of the second planar surface of the loading device, wherein the radionuclide tile carrier is adapted for positioning on the loading bed, and
a guide channel
having a longitudinal axis parallel to a longitudinal axis of the loading bed, and
sized and configured to receive a first end of the guide tool and direct the first end of the guide tool parallel to the third planar surface of the loading device into the radionuclide tile carrier positioned on the loading bed, moving the cylindrical radionuclide seed into the radionuclide tile carrier.

### Claim 2 (depends on 1)

The treatment system of claim 1, wherein the guide tool comprises a needle.

### Claim 3 (depends on 1)

The treatment system of claim 1, wherein the guide tool is configured to pull the cylindrical radionuclide seed into the radionuclide tile carrier positioned on the loading device.

### Claim 4 (depends on 1)

The treatment system of claim 1, wherein the loading device further comprises a lid configured for engagement with the first planar surface of the loading device and the second planar surface of the loading device.

### Claim 5 (depends on 4)

The treatment system of claim 4, wherein the loading device further comprises an end surface coupled to first ends of
the first planar surface of the loading device;
the second planar surface of the loading device; and
the third planar surface;
wherein the guide channel comprises a first aperture in the end surface configured to direct the first end of the guide tool into the radionuclide tile carrier on the loading bed.

### Claim 6 (depends on 5)

The treatment system of claim 5, wherein the guide channel further comprises a second aperture in the lid, the second aperture aligned with the longitudinal axis of the guide channel such that entry of the guide tool into each of the first and the second apertures directs the guide tool parallel to the first planar surface of the loading device and the second planar surface of the loading device.

### Claim 7 (depends on 4)

The treatment system of claim 4, wherein the lid comprises a loading bed insert that engages internal surfaces of the first planar surface of the loading device and the second planar surface of the loading device.

### Claim 8

A method comprising:
providing a loading device having
a first planar surface facing and parallel to a second planar surface,
a third planar surface defining a loading bed perpendicular to the first planar surface and the second planar surface, the loading bed between a first portion of the first planar surface and a second portion of the second planar surface; and
a guide channel having a longitudinal axis parallel to a longitudinal axis of the loading bed, the guide channel sized and configured to receive and direct a guide tool parallel to the first planar surface and the second planar surface;
positioning a tile radionuclide carrier on the loading bed of the loading device, the tile radionuclide carrier having a top longitudinally planar surface and a bottom longitudinally planar surface opposing the top longitudinally planar surface and parallel thereto;
inserting a first end of the guide tool through the guide channel and into the tile radionuclide carrier positioned on the loading bed, moving a cylindrical radionuclide seed through the guide channel and into the tile radionuclide carrier.

### Claim 9 (depends on 8)

The method of claim 8, further comprising:
inserting the tile radionuclide carrier into mammalian tissue.

### Claim 10

A treatment system comprising:
a radionuclide tile or gore carrier having a first longitudinally planar surface, an opposing second longitudinally planar surface parallel to the first planar surface, and a uniform thickness therebetween;
a cylindrical radionuclide seed;
a guide tool; and
a loading device having:
a first planar surface facing and parallel to a second planar surface,
a third planar surface defining a loading bed perpendicular to the first and the second planar surfaces of the loading device, the loading bed between a first portion of the first planar surface of the loading device and a second portion of the second planar surface of the loading device, wherein the radionuclide tile or gore carrier is adapted for positioning on the loading bed, and
a guide channel
having a longitudinal axis parallel to a longitudinal axis of the loading bed, and
sized and configured to receive a first end of the guide tool and direct the first end of the guide tool parallel to the third planar surface of the loading device into the radionuclide tile carrier positioned on the loading bed, moving the cylindrical radionuclide seed into the radionuclide tile carrier.