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US 9,408,994 B2Granted
Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
AssigneeGeno LLC
InventorsDavid H. Fine, David R. Rounbehler, Gregory Vasquez, Brian Johnson
Life of this patent
Estimating the term…
Abstract
A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
Claims13
A method for delivering a therapeutic gas including nitric oxide to a mammal comprising:
- introducing an air flow into a delivery system, wherein the air flow has a flow rate of between 5 and 60 liters per minute;
- releasing a gas including nitrogen dioxide from a gas source via a pressure regulator;
- diffusing the gas including nitrogen dioxide into the air flow, thereby forming an air flow including nitrogen dioxide;
- introducing the air flow including nitrogen dioxide into a receptacle including an inlet, an outlet and an antioxidant;
- converting the nitrogen dioxide to nitric oxide gas by contacting the nitrogen dioxide with the antioxidant;
- and
- delivering the nitric oxide gas to the mammal in the air flow.
4 more elements
A method for delivering a therapeutic gas including nitric oxide to a mammal comprising:
- introducing an air flow into a delivery system, wherein the air flow has a flow rate of between 5 and 60 liters per minute;
- releasing a gas including nitrogen dioxide from a gas source via a diffusion cell or a permeation tube;
- diffusing the gas including nitrogen dioxide into the air flow, thereby forming an air flow including nitrogen dioxide;
- introducing the air flow including nitrogen dioxide into a receptacle including an inlet, an outlet and an antioxidant;
- converting the nitrogen dioxide to nitric oxide gas by contacting the nitrogen dioxide with the antioxidant;
- and
- delivering the nitric oxide gas to the mammal in the air flow.
4 more elements
Dependencies are inferred from the claim text.