Biodegradable polymer—bioactive moiety conjugates
AssigneePolyactiva Pty Ltd
InventorsMichael Shane O'Shea, Florian Hans Maximillian Graichen, Russell John Tait, Heng Chy Taing, Justine Leigh Jeffery
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Abstract
The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.
Claims18
A biodegradable polyester polymer which is a copolymer of:
- a monomer—bioactive moiety conjugate of formula (II):
- where:
- X′ and Y′ are each hydroxyl;
- R represents a linear or branched optionally substituted hydrocarbon;
- Z is a spacer moiety;
- and
- D is a releasable bioactive moiety;
- and
- at least one selected from the group consisting of:
- (i) an alkyl ester of lysine diisocyanate;
- and
- (ii) a polyisocyanate and one or more polyester polyol co-monomers.
A method for preparing a biodegradable polyester polymer, said method comprising the step of polymerising a monomer-bioactive moiety conjugate of formula (II):
- where:
- X′ and Y′ are each hydroxyl;
- and
- R represents a linear or branched optionally substituted hydrocarbon;
- Z is a spacer moiety;
- and
- D is a releaseable bioactive moiety;
- with at least one selected from the group consisting of:
- an alkyl ester of lysine diisocyanate;
- and
- (ii) a polyisocyanate in the presence of one or more polyester polyol co-monomers.
Dependencies are inferred from the claim text.