# US 9,408,859 B2 · Pharmaceutical compositions useful for preventing and treating cancer

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- Number: US 9,408,859 B2
- Document ID: US9408859B2
- Status: Granted
- Kind: B2
- Application number: 13/674,443
- Filed: 2012-11-12
- Published: 2013-03-21
- Granted: 2016-08-09
- Earliest claimed: 2012-11-12
- Assignees: Mitotech SA
- Applicants: Mitotech SA
- Inventors: Vladimir P. Skulachev; Maxim V. Skulachev
- Web page: https://patentgrep.com/patent/US9408859B2

## CPC

- A61K 31/66: Phosphorus compounds
- A61K 31/4355: the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
- A61K 31/473: ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
- A61K 31/4741: condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
- A61K 47/54: the modifying agent being an organic compound
- A61K 47/545: {Heterocyclic compounds (A61K47/558 takes precedence)}
- A61P 35/00: Antineoplastic agents
- A61P 39/06: Free radical scavengers or antioxidants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed is a method of treating a cancer on a mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of a compound

## Claims

### Claim 1

A method of treating a cancer in a mammal, wherein the cancer is selected from the group consisting of cervical carcinoma, fibrosarcoma, osteosarcoma, and rhabdomyosarcoma, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition of a compound having the structural formula:

### Claim 2 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is administered with another anti-cancer therapeutic.

### Claim 3 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is a solution and is orally administered.

### Claim 4 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is a solution and is parenterally administered.

### Claim 5 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is an ointment, bandage, or film and is transdermally administered.

### Claim 6 (depends on 1)

The method of claim 1, wherein the cancer is a Ras-related metastatic cancer.

### Claim 7

A method of treating a cancer in a mammal, wherein the cancer is selected from the group consisting of fibrosarcoma, osteosarcoma, and rhabdomyosarcoma, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition of one or more compound having a structural formula selected from:

### Claim 8 (depends on 7)

The method of claim 7, wherein the pharmaceutical composition is administered with another anti-cancer therapeutic.

### Claim 9 (depends on 7)

The method of claim 7, wherein the pharmaceutical composition is a solution and is orally administered.

### Claim 10 (depends on 7)

The method of claim 7, wherein the pharmaceutical composition is a solution and is parenterally administered.

### Claim 11 (depends on 7)

The method of claim 7, wherein the pharmaceutical composition is an ointment, bandage, or film and is transdermally administered.

### Claim 12 (depends on 7)

The method of claim 7, wherein the cancer is a Ras-related metastatic cancer.

### Claim 13

A method of treating a cancer in a mammal, wherein the cancer is selected from the group consisting of osteosarcoma and rhabdomyosarcoma, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition of one or more compound having a structural formula selected from

### Claim 14 (depends on 13)

The method of claim 13, wherein the pharmaceutical composition is administered with another anti-cancer therapeutic.

### Claim 15 (depends on 13)

The method of claim 13, wherein the pharmaceutical composition is a solution and is orally administered.

### Claim 16 (depends on 13)

The method of claim 13, wherein the pharmaceutical composition is a solution and is parenterally administered.

### Claim 17 (depends on 13)

The method of claim 13, wherein the pharmaceutical composition is an ointment, bandage, or film and is transdermally administered.

### Claim 18 (depends on 13)

The method of claim 13, wherein the cancer is a Ras-related metastatic cancer.