Nucleic acid molecule encoding hepatitis B virus core protein and vaccine comprising the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid B. Weiner, Jian Yan, Nyamekye Obeng-Adjei
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Abstract
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequence of HBV core protein, as well as genetic constructs/vectors and vaccines that express said protein sequences. Also provided herein are methods for generating an immune response against HBV using the nucleic acid sequences that are provided.
Claims21
A nucleic acid molecule comprising a nucleic acid sequence encoding the protein of SEQ ID NO:
- 1.
A protein consisting of SEQ ID NO:
- 1.
A protein selected from the group consisting of:
- SEQ ID NO:2;
- SEQ ID NO:4 and SEQ ID NO:6.
A nucleic acid molecule comprising a nucleic acid sequence encoding one or more proteins selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 4 and SEQ ID NO:
- 6.
A nucleic acid molecule comprising one or more nucleotide sequences selected from the group consisting of:
- SEQ ID NO:1;
- SEQ ID NO:3;
- and SEQ ID NO:5.
Dependencies are inferred from the claim text.