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US 9,402,916 B2Granted
Re-directed immunotherapy
AssigneeThe University of Birmingham
InventorsMark Cobbold, David Millar
Life of this patent
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Abstract
The invention provides an agent for preventing or treating a condition characterized by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.
Claims17
A method of retargeting T cells to cancer cells, the method comprising administering an agent for treating cancer to a human subject in need thereof, wherein the agent comprises:
- i) a targeting moiety that is capable of targeting to the cancer cells, wherein the targeting moiety is an antibody or antigen binding fragment thereof that binds a tumor antigen;
- and
- ii) a viral T cell epitope that elicits an existing immune response in the subject and binds to a HLA molecule on the surface of the cancer cell of the human subject and has a HLA matched to the subject, and
- iii) a peptide linker comprising a peptide cleavage site cleavable by a tumor associated protease and
- wherein the linker can be selectively cleaved by the tumor associated protease to release the T cell epitope in the vicinity of, and outside of, the cancer cell.
2 more elements
Dependencies are inferred from the claim text.