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US 9,402,892 B2Granted
Inactivated poliovaccine
AssigneeThe Secretary of State for Health
InventorAndrew MacAdam
Life of this patent
Estimating the term…
Abstract
The invention provides an attenuated polio virus having a 5′ non-coding region consisting of the 5′ non-coding region of Sabin 3, modified so that it does not have a base pair mismatch in stem (a) or (b) of domain V, wherein seven or eight of the base pairs in stems (a) and (b) are U-A or A-U base pairs; and a capsid protein from the Sabin 1, Mahoney, MEF or Saukett strain.
Claims13
An attenuated recombinant poliovirus having:
- (i) a 5′ non-coding region consisting of the 5′ non-coding region of Sabin 3 strain of poliovirus, modified so that it does not have a base pair mismatch in stem (a) or (b) of domain V, wherein seven or eight of the base pairs in stems (a) and (b) are U-A or A-U base pairs, and wherein:
- (a) a U-A base pair is present:
- (I) in stem (a) with nucleotide pairs U471 and A538 and U472 and A537;
- and
- (II) in stem (b) with nucleotide pairs U478 and A533, U480 and A531, and U481 and A530;
- and
- (b) an A-U base pair is present:
- (I) in stem (b) with nucleotide pairs A479 and U532 and A482 and U529;
- or
- (c) a U-A base pair is present:
- (I) in stem (a) with nucleotide pairs U471 and A538 and U472 and A537;
- and
- (II) in stem (b) with nucleotide pairs U478 and A533, U480 and A531, and U481 and A530;
- and
- (d) an A-U base pair is present in stem (b) with nucleotide pairs A477 and U534, A479 and U532, and A482 and U529;
- (ii) a protease 2A coding region from Sabin 3;
- and
- (iii) an entire capsid protein coding region P1 from the Sabin 1, Mahoney, MEF, or Saukett strain of poliovirus.
15 more elements
Dependencies are inferred from the claim text.