Compositions and methods for treating cancer
AssigneeThe Trustees of the University of Pennsylvania
InventorsDaniel J. Powell, George Coukos
Life of this patent
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Abstract
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
Claims34
An isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the isolated nucleic acid sequence comprises a nucleic acid sequence encoding an anti-α-folate receptor (FRα) antibody or fragment thereof comprising the amino acid sequence of SEQ ID NO:
- 23 and a 4-1BB (CD 137) costimulatory domain.
An isolated chimeric antigen receptor (CAR), wherein the CAR comprises an anti-α-folate receptor (FRα) antibody or fragment thereof comprising the amino acid sequence of SEQ ID NO:
- 23 and a 4-1BB (CD 137) costimulatory domain.
Dependencies are inferred from the claim text.