Compositions and methods of using threohydroxybupropion for therapeutic purposes
AssigneeAntecip Bioventures II LLC
InventorHerriot Tabuteau
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Abstract
This disclosure relates to methods administering threohydroxybupropion or a prodrug thereof in conjunction with dextromethorphan to a human being. Dosage forms, drug delivery systems, and methods related to dextromethorphan or dextrorphan and threohydroxybupropion or a prodrug of threohydroxybupropion are also disclosed.
Claims18
A method of increasing dextromethorphan plasma levels in a human being, comprising co-administering threohydroxybupropion with dextromethorphan to the human being for at least eight consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein threohydroxybupropion and dextromethorphan are the sole active agents administered to the human being, wherein the threohydroxybupropion is administered in an amount that results in an AUC0-12 of dextromethorphan that is at least 40 ng·hr/mL, and wherein, on the eighth day that threohydroxybupropion and dextromethorphan are co-administered, the AUC0-12 of dextromethorphan is at least 20 times the AUC0-12 of dextromethorphan that would result from administering the same amount of dextromethorphan without threohydroxybupropion.
A method of increasing dextromethorphan plasma levels in a human being, comprising co-administering threohydroxybupropion with dextromethorphan to the human being for at least eight consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein threohydroxybupropion and dextromethorphan are the sole active agents administered to the human being, wherein the threohydroxybupropion is administered in an amount that results in a Cmax of dextromethorphan that is at least 6 ng/mL, and wherein, on the eighth day that threohydroxybupropion and dextromethorphan are co-administered, the AUC0-12 of dextromethorphan is at least 20 times the AUC0-12 of dextromethorphan that would result from administering the same amount of dextromethorphan without threohydroxybupropion.
A method of increasing dextromethorphan plasma levels in a human being, comprising co-administering threohydroxybupropion with dextromethorphan to the human being for at least eight consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein threohydroxybupropion and dextromethorphan are the sole active agents administered to the human being, wherein the threohydroxybupropion is administered in an amount that results in a Cavg of dextromethorphan, over the period between two separate and consecutive administrations of dextromethorphan, that is at least 5 ng/mL, and wherein, on the eighth day that threohydroxybupropion and dextromethorphan are co-administered, the AUC0-12 of dextromethorphan is at least 20 times the AUC0-12 of dextromethorphan that would result from administering the same amount of dextromethorphan without threohydroxybupropion.
Dependencies are inferred from the claim text.