Snuff composition
AssigneeNiconovum USA, Inc.
InventorsAnders Axelsson, Arne Kristensen, Henri Hansson
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Abstract
Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.
Claims28
A nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein
- i) the nicotine-cellulose combination is a solid material composed of a cellulose, which has sorbed an amount of nicotine in voids or pores within the cellulose,
- ii) the concentration of the nicotine-cellulose combination in the composition is from 80% to 98% w/w,
- iii) the concentration of nicotine in the composition is from about 0.1 to 10% w/w, and
- iv) the composition, when subjected to an in vitro dissolution test, about 30% or more of the total content of nicotine is released within 30 minutes, and the in vitro dissolution test being in accordance with the method described herein under the heading “In vitro dissolution test”, subheading “Snuff”.
The composition of clam 1 wherein the composition—when subjected to said in vitro dissolution test—releases about 45% or more within 20 minutes.
A snuff composition comprising a nicotine-cellulose combination and one or more acceptable excipients, wherein
- i) the nicotine-cellulose combination is a solid material composed of a cellulose, which has sorbed an amount of nicotine in voids or pores within the cellulose,
- ii) the concentration of the nicotine-cellulose combination in the composition is from 80% to 98% w/w,
- iii) the concentration of nicotine in the composition is from about 0.1 to 10% w/w, and
- iv) the composition, when subjected to an in vitro dissolution test, about 30% or more of the total content of nicotine is released within 30 minutes, and the in vitro dissolution test being in accordance with the method described herein under the heading “In vitro dissolution test”, subheading “Snuff”.
Dependencies are inferred from the claim text.