PVRL4 (Nectin4) is a receptor for measles virus
AssigneeChristopher D. Richardson
InventorChristopher D. Richardson
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Abstract
PVRL4 is a tumor marker that is highly expressed on the surfaces of many carcinomas. Disclosed herein are compositions and methods that provide impetus for using measles virus as an oncolytic agent against PVRL4+ carcinomas and use of PVRL4-binding agents to interfere with viral infection.
Claims16
A method for reducing the size of a tumor in a mammal having a tumor expressing the poliovirus receptor-related 4 (PVRL4), comprising administering a wild-type measles virus via injection to the mammal such that the wild-type measles virus binds to PVRL4 and reduces the size of the tumor expressing PVRL4.
A method of infecting a cell expressing PVRL4 with a wild-type measles virus, comprising injecting the cell with the wild-type measles virus.
Dependencies are inferred from the claim text.