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US 9,394,235 B2Granted
Optical resolution methods for bicyclic compounds using enzymes
AssigneeDaiichi Sankyo Company, Limited
InventorsYoshitaka Nakamura, Yukito Furuya, Kousei Shimada, Yoshiyuki Onishi
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Abstract
An object of the present invention is to efficiently produce an optically active bicyclic compound. The optically active bicyclic compound is efficiently produced using an enzyme.
Claims8
A method of producing a compound of formula (I):
- comprising:
- (1) allowing a racemic mixture of the compound of formula (I) and a compound of formula (II)
- to react in the presence of:
- a reductase or an alcohol dehydrogenase,
- a coenzyme, and
- a compound selected from formic acid, a salt of formic acid, glucose and a combination of the foregoing,
- in a buffer solution to convert the compound of formula (II) to a compound of formula (II′):
- wherein R1 is an ethyl group,
- and
- (2) separating the compound of formula (I) from the compound of formula (II′) to produce the compound of formula (I).
7 more elements
Dependencies are inferred from the claim text.