Treprostinil derivatives and compositions and uses thereof

A compound of Formula (I):

• wherein:
• R1 and R2 independently are hydrogen,
• wherein:
• R3 in each occurrence independently is alkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which may optionally be substituted;
• R4 and R5 in each occurrence independently are hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl, or R4 and R5 and the carbon atom to which they are connected form a C3-C6 cycloalkyl ring;
• R6 in each occurrence independently is hydrogen, R3, —C(═O)R3, —C(═O)OR3 or —C(═O)NR9R10;
• or
• R6 and R4 or R5, together with the atoms to which they are connected, form a heterocyclic ring;
• R9 and R10 in each occurrence independently are hydrogen, alkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl;
• or
• R9 and R10 and the nitrogen atom to which they are connected form a heterocyclic or heteroaryl ring;
• j in each occurrence independently is an integer from 0 to 4;
• and
• m in each occurrence independently is an integer from 1 to 10;
• or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof, with the proviso that:
• both R1 and R2 are not hydrogen;
• neither —OR1 nor —OR2 forms an acetate;
• neither —OR1 nor —OR2 forms a substituted cyclohexane-ester;
• and
• neither —OR1 nor —OR2 forms an ester with or of an amino acid (protected or unprotected), a peptide or a protein.