Compounds for targeting drug delivery and enhancing siRNA activity

A stellate-cell-specific drug carrier comprising a stellate cell specific amount of a retinoid molecule consisting of the structure (retinoid)m-linker-(retinoid)n;

• wherein m and n are independently 1, 2, or 3;
• wherein the linker comprises one or more elements selected from a polyethylene glycol (PEG), glutarate (Glu), hexyl, Gly3, and 4-aminobutanoate (GluNH).

A compound for facilitating drug delivery to a target cell, consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule consists of a retinoid or a fat soluble vitamin having a specific receptor on the target cell;

• wherein m and n are 1 or 2;
• wherein m+n=3;
• and wherein the linker comprises one or more elements selected from bis-amido-polyethylene glycol (PEG), tris-amido-PEG, tetra-amido-PEG, Lys-bis-amido-PEG Lys, Lys-tris-amido-PEG-Lys, Lys-tetra-amido-PEG-Lys, Lys-PEG-Lys, PEG2000, PEG1250, PEG1000, PEG750, PEG550, PEG-Glu, glutarate (Glu), hexyl, Gly3, and 4-aminobutanoate (GluNH).