# US 9,392,949 B2 · Ventricular pacing in cardiac-related applications > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,392,949 B2 - Document ID: US9392949B2 - Status: Granted - Kind: B2 - Application number: 14/433,372 - Filed: 2013-10-02 - Published: 2015-09-17 - Granted: 2016-07-19 - Earliest claimed: 2012-10-02 - Assignees: XSynchro, Inc. - Applicants: XSynchro, Inc. - Inventors: Daniel Felipe Ortega; Julio César Spinelli; Maria Paula Bonomini; Luis Dante Barja - Web page: https://patentgrep.com/patent/US9392949B2 ## CPC - A61N 1/3684: {for stimulating the heart at multiple sites of the ventricle or the atrium} - A61B 5/341: Vectorcardiography [VCG] - A61B 5/346: Analysis of electrocardiograms - A61B 5/352: Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval - A61B 5/366: Detecting abnormal QRS complex, e.g. widening - A61N 1/056: {Transvascular endocardial electrode systems} - A61N 1/36514: {controlled by a physiological quantity other than heart potential, e.g. blood pressure (controlled by two or more physical parameters A61N1/36585)} - A61N 1/36542: {controlled by body motion, e.g. acceleration} - A61N 1/36564: {controlled by blood pressure} - A61N 1/36585: {controlled by two or more physical parameters} - A61N 1/3682: {with a variable atrioventricular delay} - A61N 1/36842: {Multi-site stimulation in the same chamber} - A61N 1/36843: {Bi-ventricular stimulation} - A61N 1/3688: {configured for switching the pacing mode, e.g. from AAI to DDD} - G16H 50/30: for calculating health indices; for individual health risk assessment - A61N 1/37254: {Pacemaker or defibrillator security, e.g. to prevent or inhibit programming alterations by hackers or unauthorised individuals} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract Various aspects of the present disclosure are directed toward an asynchrony index that is related to data of a subject's heart. The asynchrony index includes intra-ventricular or inter-ventricular electrical asynchrony data. The intra-ventricular or inter-ventricular electrical asynchrony data can be specific to a certain subject, and indicative of a different conditions specific to that subject. ## Claims ### Claim 1 An apparatus comprising: an acquisition circuit configured and arranged to collect a first signal at a first location of a subject's heart and a second signal at a second location of the subject's heart, the first signal being indicative of at least one of a first heart surface electrocardiography (ECG) and a first intracardiac electrogram (EG), and the second signal being indicative of at least one of a second heart surface ECG and a second intracardiac electrogram (EG); preprocessing circuitry configured and arranged to perform detection and filtering of QRS complexes of the first signal and the second signal collected by the acquisition circuit; analysis circuitry configured and arranged to: from the first signal and the second signal, extract signal information comprising one or more of parameters and data points, segment the QRS complexes of the first signal and the second signal using the extracted information, cross-correlate the QRS complex segments of the first signal and the second signal to produce a correlation signal, and provide an asynchrony index that at least one of is based on and corresponds to the correlation signal and that indicates a level of electrical asynchrony between the first location and the second location. ### Claim 2 (depends on 1) An apparatus according to claim 1, further comprising intracardiac electrodes, coupled to the acquisition circuit, configured and arranged to collect the first signal and the second signal, and to stimulate the subject's heart. ### Claim 3 (depends on 1) An apparatus according to claim 1, wherein the analysis circuitry is further configured and arranged to determine whether the asynchrony index is conclusive, and in response to the asynchrony index being inconclusive, measure the QRS width by performing one of the following: bandpass filter the first signal and the second signal at 5-15 Hz to enhance the QRS complex; and locate the peak of the complex via determining a maximum for R waves and minimum for Q-S waves. ### Claim 4 (depends on 1) An apparatus according to claim 1, wherein the extracted information comprises timing of the QRS complex by detection of R or S waves, the correlation signal comprises at least one of Tshift, which comprises a delay between peak obtained from the correlation signal, or Xcorrwidth, which comprises a width of the correlation signal, and the analysis circuitry is further configured and arranged to extract the parameter Tshift from the correlation signal as a measure of time displacement between an activation of the two surfaces of the heart collect from the first signal and the second signal. ### Claim 5 (depends on 1) An apparatus according to claim 1, wherein the analysis circuitry is further configured and arranged to extract Xcorrwidth, which comprises a width of the correlation signal, from the correlation signal as a measure of difference in shape between the first signal and the second signal. ### Claim 6 (depends on 1) An apparatus according to claim 1, wherein the analysis circuitry is further configured and arranged to calculate a Fourier Transform or a fast Fourier Transform of the correlation signal between the first signal and the second signal. ### Claim 7 (depends on 1) An apparatus according to claim 1, wherein the analysis circuitry is further configured and arranged to calculate an energy ratio of a low frequency band of the cross-correlation signal relative to a total energy of the correlation signal energy spectrum. ### Claim 8 (depends on 1) An apparatus according to claim 1, wherein the extracted information comprises information regarding vectocardigraphical data, and wherein the asynchrony index is zero if the vectocardigraphical data is normal, and the asynchrony index is maximal when the vectocardigraphical data is maximally abnormal. ### Claim 9 (depends on 1) An apparatus according to claim 1, wherein the analysis circuitry is further configured and arranged to increase the asynchrony index by a first predetermined factor when both signals have opposite to normal polarities, to increase the asynchrony index by a second predetermined factor, that is less than the first predetermined factor, when the first and second signals have different respective polarities in that one is normal and the other is abnormal. ### Claim 10 (depends on 1) An apparatus according to claim 1, wherein the extracted information comprises at least one of amplitudes of the QRS complexes, and a mean or average of peak-to-peak amplitudes of the QRS complexes. ### Claim 11 (depends on 1) An apparatus according to claim 1, wherein the acquisition circuit is further configured and arranged to collect the first signal and the second signal as corresponding to the first EG and the second EG. ### Claim 12 (depends on 1) An apparatus of claim according to claim 1, wherein the acquisition circuit is further configured and arranged to collect the first signal and the second signal as corresponding to the first ECG and the second ECG. ### Claim 13 (depends on 1) An apparatus according to claim 1, further comprising: an implantable device configured and arranged to cycle through at least one of one or more interventricular delay (VV) intervals and one or more atrio-ventricular (AV) intervals inside a pre-determined safety range and to calculate electrograms, the electrograms comprising the first intracardiac electrogram and the second intracardiac electrogram, obtained by the device during implantation; and the analysis circuitry further configured and arranged to determine the asynchrony index of the subject based on one or more of the electrograms. ### Claim 14 (depends on 13) An apparatus according to claim 13, further comprising: the analysis circuitry configured to determine the AV delay interval associated with a lowest one of the determined synchrony indices as the optimal AV delay interval. ### Claim 15 (depends on 13) An apparatus according to claim 13, further comprising: the analysis circuitry further configured to determine the VV delay Interval associated with a lowest one of the determined synchrony indices as the optimal VV delay interval. ### Claim 16 (depends on 15) An apparatus according to claim 15, further comprising: an arterial pulse pressure sensor configured to measure arterial pulse pressure of the subject; and the analysis circuitry configured to determine one of the AV intervals as the optimal Av interval based on the arterial pulse pressure measured in response to the cycling of that AV interval, wherein the implantable device maintains the optimal VV interval as the VV interval that minimizes the asynchrony index while cycling through the AV intervals to select the optimal interval. ### Claim 17 (depends on 16) An apparatus according to claim 16, further comprising: the analysis circuitry further configured to average the measured arterial pulse pressure for each of the cycled AV intervals, wherein the optimal AV interval is associated with the largest average arterial pulse and the lowest asynchrony index simultaneously occurring at any of the AV intervals when compared to the average pulse pressures and asynchrony indexes for the remaining AV intervals. ### Claim 18 (depends on 16) An apparatus according to claim 16, further comprising: the analysis circuitry further configured to average a full member of respiratory cycles of the subject to eliminate the subject's respiration as a source of variation of the measured arterial pulse pressure. ### Claim 19 (depends on 13) An apparatus according to claim 13, wherein the implantable device is at least one of a pacemaker and a cardiac resynchronization therapy device. ### Claim 20 (depends on 1) An apparatus according to claim 1, further comprising circuitry that is communicatively coupled with the analysis circuitry and that is used to provide a based on the asynchrony index a pacing change of a device configured and arranged to be implanted in the subject.