Molecular profiling of tumors

A system for generating a report identifying at least one therapeutic agent for an individual with a cancer comprising:

• a. at least one device configured to assay a plurality of molecular targets in a biological sample from the individual to determine molecular profile test values for the plurality of molecular targets, wherein the molecular targets comprise ATRX, BRAF, CDH1 , CDKN1B, CDKN2A, ERBB4, KRAS, MET, MYC, RAD51, and WISP3;
• and
• b. at least one computer database comprising:
• i. a reference value for each of the plurality of molecular targets;
• and
• ii. a listing of therapeutic agents with efficacy linked to a biological state of at least one member of the plurality of molecular targets;
• c. a computer-readable program code comprising instructions to input the molecular profile test values and to compare each of the molecular profile test values with a corresponding reference value in (b)(i) to identify a biological state for each member of the plurality of molecular targets;
• d. a computer-readable program code comprising instructions to identify at least one therapeutic agent from the listing of therapeutic agents in (b)(ii), wherein the biological state identified in (c) for at least one member of the plurality of molecular targets provides an indication of likely benefit of the at least one therapeutic agent for treating the cancer;
• and
• e. a computer-readable program code comprising instructions to generate a report that comprises a listing of the at least one therapeutic agent identified in (d) and the biological state of each molecular target with efficacy linked thereto.