Compositions and methods of using islet neogenesis peptides and analogs thereof
AssigneeShenzhen HighTide Biopharmaceutical, Ltd.
InventorsLiping Liu, Ru Bai
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Abstract
The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.
Claims46
A peptide comprising an amino acid sequence selected from the group consisting of IGLHDPSHGTLPAG (SEQ ID NO:73) and IGLHDPTQGTEPAG (SEQ ID NO:118), and a peptide analog comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 10-15, 28-30, 41, 43-45, 47-49, 51-53, 60, 62, 68 and 70-72.
Dependencies are inferred from the claim text.