Production method for cyclopentanone derivative, intermediate compound, and production method for intermediate compound
AssigneeKureha Corporation
InventorsShigeyuki Kikumoto, Hisashi Kanno
Life of this patent
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Abstract
The present invention is a production method for a compound represented by the following general formula (V), the method comprising a step of obtaining a compound represented by the following general formula (II) by reacting a compound represented by the following general formula (I) with an acid: wherein, G1 and G2 are each a protecting group that dissociates under acidic conditions.
Claims9
A production method for a compound represented by formula (III), comprising:
- obtaining a compound represented by formula (III) below by reacting a compound represented by formula (II) with a compound selected from the group consisting of a formaldehyde, paraformaldehyde, 1,3,5-trioxane, and formaldehyde dialkyl acetal:
- in formula (II), X is a halogen atom, an alkyl group having from 1 to 4 carbons, a haloalkyl group having from 1 to 4 carbons, an alkoxy group having from 1 to 4 carbons, a haloalkoxy group having from 1 to 4 carbons, a phenyl group, a cyano group, or a nitro group;
- m is an integer from 0 to 5;
- a plurality of X moieties may be the same or different when m is 2 or greater;
- and
- in formula (III), X and m are each the same as X and m in formula (II).
A production method for a compound represented by formula (IV), comprising:
- obtaining a compound represented by formula (IV) below by reacting a compound represented by formula (III) with protecting groups that dissociate under acidic conditions:
- in formula (III), X is a halogen atom, an alkyl group having from 1 to 4 carbons, a haloalkyl group having from 1 to 4 carbons, an alkoxy group having from 1 to 4 carbons, a haloalkoxy group having from 1 to 4 carbons, a phenyl group, a cyano group, or a nitro group;
- m is an integer from 0 to 5;
- a plurality of X moieties may be the same or different when m is 2 or greater;
- and
- in formula (IV), X and m are each the same as X and m in formula (III);
- and G1 and G2 each represents a protecting group that dissociates under acidic conditions, G1 and G2 may be the same or different, and G1 and G2 may bond with one another to form a ring.
A production method for a cyclopentanone derivative represented by formula (V), comprising:
- obtaining a compound represented by formula (V) by dehydroxymethylating a compound represented by formula (IV) under basic conditions:
- in formula (V), X is a halogen atom, an alkyl group having from 1 to 4 carbons, a haloalkyl group having from 1 to 4 carbons, an alkoxy group having from 1 to 4 carbons, a haloalkoxy group having from 1 to 4 carbons, a phenyl group, a cyano group, or a nitro group;
- m is an integer from 0 to 5;
- a plurality of X moieties may be the same or different when m is 2 or greater;
- G1 and G2 each represents a protecting group that dissociates under acidic conditions, G1 and G2 may be the same or different, and G1 and G2 may bond with one another to form a ring;
- and
- in formula (IV), X, m, G1, and G2 are each the same as X, m, G1, and G2 in formula (V).
Dependencies are inferred from the claim text.