Interpenetrating networks with covalent and Ionic Crosslinks
AssigneesPresident and Fellows of Harvard College, Seoul National University Industry Foundation
InventorsJeong-Yun Sun, Xuanhe Zhao, Widusha R. K. Illeperuma, Kyu Hwan Oh, Joost J. Vlassak, Zhigang Suo, Jianyu Li, David J. Mooney
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Abstract
The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
Claims40
A composition comprising a self-healing interpenetrating networks hydrogel comprising a first network and a second network, wherein said first network comprises covalent crosslinks and said second network comprises ionic or physical crosslinks, wherein said first network comprises a polymer selected from the group consisting of polyacrylamide, poly(vinyl alcohol), poly(ethylene oxide) and its copolymers, polyethylene glycol (PEG), methacrylated PEG, and polyphosphazene;
- said second network comprises an alginate polymer;
- wherein the Young's modulus of the hydrogel is at least 10.0 kPa, wherein said interpenetrating networks hydrogel comprises a stretch value (λ) of about 21.
A composition comprising a self-healing interpenetrating networks hydrogel comprising a first network and a second network, wherein said first network comprises covalent crosslinks and said second network comprises ionic or physical crosslinks, wherein said first network and said second network are covalently coupled, wherein said first network comprises a polymer selected from the group consisting of polyacrylamide, poly(vinyl alcohol), poly(ethylene oxide) and its copolymers, polyethylene glycol (PEG), methacrylated PEG, and polyphosphazene;
- said second network comprises an alginate polymer;
- and wherein the Young's modulus of the hydrogel is at least 10.0 kPa.
A method of making a self-healing interpenetrating networks hydrogel comprising a first network and a second network, wherein said first network comprises covalent crosslinks and said second network comprises ionic crosslinks;
- wherein said first network and said second network are covalently coupled, and wherein the Young's modulus of the hydrogel is at least 10.0 kPa, the method comprising
- mixing an alginate and acrylamide polymer in a weight ratio of acrylamide to (acrylamide plus alginate) from 66.67 wt. % to 94.12 wt. %;
- and
- contacting the mixture with a covalent crosslinking agent and an ionic crosslinking agent thereby making a self-healing interpenetrating networks hydrogel.
A composition comprising a self-healing interpenetrating networks hydrogel comprising a first network and a second network, wherein said first network comprises covalent crosslinks and said second network comprises ionic or physical crosslinks, wherein said first network and said second network are covalently coupled, wherein said first network comprises a polymer selected from polyethylene glycol (PEG) and methacrylated PEG and said second network comprises an alginate polymer.
A composition comprising a self-healing interpenetrating networks hydrogel comprising a first network and a second network, wherein said first network comprises covalent crosslinks and said second network comprises ionic or physical crosslinks, wherein said first network comprises a polymer selected from the group consisting of polyacrylamide, poly(vinyl alcohol), poly(ethylene oxide) and its copolymers, polyethylene glycol (PEG), methacrylated PEG, and polyphosphazene;
- said second network comprises an alginate polymer;
- wherein the Young's modulus of the hydrogel is about 5 MPa.
A composition comprising a self-healing interpenetrating networks hydrogel comprising a first network and a second network, wherein said first network comprises covalent crosslinks and said second network comprises ionic or physical crosslinks, wherein said first network and said second network are covalently coupled, wherein said first network comprises a polymer selected from the group consisting of polyethylene glycol (PEG) and methacrylated PEG;
- said second network comprises an alginate polymer;
- and wherein the Young's modulus of the hydrogel is at least 10.0 kPa.
Dependencies are inferred from the claim text.