Osteoimplant and method of making same
AssigneeWarsaw Orthopedic, Inc.
InventorsAlbert Manrique, Jean T. Edwards, Nelson L. Scarborough, Scott D. Boden, Kathy Traianedes, Lawrence A. Shimp, James L. Russell
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Abstract
An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
Claims47
An osteoimplant which comprises elongate bone particles selected from the group consisting of fully mineralized elongate bone particles, fully demineralized elongate bone particles, substantially fully mineralized elongate bone particles, partially demineralized elongate bone particles, superficially demineralized elongate bone particles, and mixtures thereof wherein mutually contacting elongate bone particles are entangled with each other;
- wherein the entangled bone particles form a coherent aggregate matrix, wherein the coherent aggregate matrix possesses an open pore, flexible, sponge-like structure configured to absorb fluids while generally retaining predetermined dimensions;
- and
- wherein the osteoimplant comprises a core composed of the fully demineralized elongate bone particles which have not been compacted and an outer surface composed of the superficially demineralized elongate bone particles which have not been compacted surrounding the core.
An osteoimplant which comprises elongate bone particles selected from the group consisting of substantially fully mineralized elongate bone particles, partially demineralized elongate bone particles, superficially demineralized elongate bone particles, and mixtures thereof, wherein mutually contacting elongate bone particles are entangled with each other;
- wherein the entangled bone particles form a coherent aggregate matrix, wherein the coherent aggregate matrix possesses an open pore, flexible, sponge-like structure configured to absorb fluids while generally retaining predetermined dimensions;
- and
- wherein the osteoimplant comprises a core composed of the superficially demineralized elongate bone particles which have not been compacted and an outer surface composed of the partially demineralized elongate bone particles which have not been compacted surrounding the core, wherein the non-compacted superficially demineralized elongate bone particles that make up the core of the osteoimplant contain a higher percentage of their original mineral content than do the non-compacted partially demineralized elongate bone particles that make up the outer surface of the osteoimplant.
An osteoimplant which comprises a carrier, a wetting agent and a coherent aggregate matrix of elongate bone particles having a median length of from about 0.05 mm to about 200 mm and a ratio of median length to median width of from about 10:1 to about 2000:1, the osteoimplant having the elongate bone particles distributed throughout, the elongate bone particles selected from the group consisting of substantially fully mineralized elongate bone particles, partially demineralized elongate bone particles, superficially demineralized elongate bone particles, fully demineralized elongate bone particles, and mixtures thereof, wherein mutually contacting elongate bone particles are entangled with each other;
- wherein the aggregate matrix possess an open pore, flexible, sponge-like structure and is configured to absorb fluids while generally retaining a predetermined dimension;
- wherein the wetting agent comprises a liquid polyhydroxy compound;
- and
- wherein the osteoimplant comprises a core composed of the superficially demineralized elongate bone particles which have not been compacted and an outer surface composed of the fully demineralized elongate bone particles which have not been compacted surrounding the core.
Dependencies are inferred from the claim text.