VLPS derived from cells that do not express a viral matrix or core protein
AssigneeNovavax, Inc.
InventorsGale Smith, Peter Pushko, Kutub Mahmood, Bin Zhou
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Abstract
The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins. The invention includes antigenic formulations and vaccines comprising VLPs of the invention as well as methods of making and administering VLPs to vertebrates, including methods of inducing immunity to infections, such as influenza.
Claims21
A virus-like particle (VLP) comprising a first influenza membrane protein and a second influenza membrane protein, wherein the first influenza membrane protein is a hemagglutinin (HA) protein and the second influenza membrane protein is a neuraminidase (NA) protein, wherein the VLP does not comprise any viral matrix or core protein, and wherein the VLP does not carry genetic information encoding proteins.
A virus-like particle (VLP) comprising influenza proteins, wherein the influenza proteins consist of an influenza hemagglutinin (HA) protein and a influenza neuraminidase (NA) protein, wherein the VLP does not comprise any viral matrix or core protein, and wherein the VLP does not carry genetic information encoding proteins.
Dependencies are inferred from the claim text.