US 9,376,448 B2 · DNA-PK inhibitors

DNA-PK inhibitors

AssigneeVertex Pharmaceuticals Incorporated

InventorsPaul S. Charifson, Kevin Michael Cottrell, Hongbo Deng, John P. Duffy, Huai Gao, Simon Giroux, Jeremy Green, Katrina Lee Jackson, Joseph M. Kennedy, David J. Lauffer, Mark Willem Ledeboer, Pan Li, John Patrick Maxwell, Mark A. Morris, Albert Charles Pierce, Nathan D. Waal, Jinwang Xu

Life of this patent

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Abstract

The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Claims10

Dependent claims

A compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

14/056,560Filed 17 Oct 2013 · continuation in part

Priority

24 Apr 2012

Published

US 2014/0045869 A113 Feb 2014

Granted

28 Jun 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification36 codes

C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
A61K 9/20
Medicinal preparations characterised by special physical form: pills, tablets, discs, rods
A61K 9/48
Medicinal preparations characterised by special physical form: preparations in capsules, e.g. of gelatin, of chocolate
A61K 31/506
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: not condensed and containing further heterocyclic rings

Family

Application61/637,512Us provisional application · filed 24 Apr 2012

Application61/725,652Us provisional application · filed 13 Nov 2012

Application61/777,806Us provisional application · filed 12 Mar 2013

Application13/868,703Parent of this continuation-in-part · filed 23 Apr 2013

US 2014/0045869 A1Pre-grant publication · published 13 Feb 2014

US 2013/0281431 A1Published application

US 9,296,701 B2Related patent

US 9,376,448 B2This patent

From the US filing history. Foreign family members aren’t listed.