Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunisation method, composition, and treatment methods for rotavirus infections
AssigneeInstituto Nacional De Technologia Agropecuaria (Inta)
InventorsThomas Surrey, Aurelien Olichon, Lorena Laura Garaicoeachea, Gisela Ariana Marcoppido, Gladys Viviana Parreño, Silvia Gómez Sebastián, José Angel Martínez Escribano, Andrés Wigdorovitz
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Abstract
Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunization method, and treatment method for rotavirus infections, wherein said domain may be any of the amino acid sequences shown in SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3, and wherein said domains bind to protein VP6 of Group A rotavirus.
Claims14
A dimeric or monomeric VHH domain characterized in that said domain comprises at least one sequence selected from the group consisting of:
- SEQ ID NO:
- 1, SEQ ID NO:
- 2, and SEQ ID NO:
- 3.
A rotavirus immunodetection method, said method comprising:
- a) contacting a rotavirus-containing sample with an amino acid sequence selected from the group consisting of:
- SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, and combinations thereof;
- and b) detecting the rotavirus.
A composition designed to confer passive immunity to a mammal, the composition comprising:
- an amino acid sequence selected from the group consisting of:
- SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, and combinations thereof;
- excipients;
- and immunomodulators.
A kit for immunodetection of rotavirus comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, and combinations thereof.
A method for treating infections produced by rotavirus, said method comprising administering an effective quantity of an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:3, and combinations thereof, to a mammal that needs it.
Dependencies are inferred from the claim text.