US 9,371,366 B2Granted

Influenza virus vaccines and uses thereof

AssigneeIcahn School of Medicine at Mount Sinai

InventorsAdolfo Garcia-Sastre, Peter Palese, Florian Krammer

Life of this patent

Estimating the term…

Abstract

Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.

Claims26

Dependent claims

A chimeric influenza virus hemagglutinin (HA) polypeptide comprising:

(a) the stem domain of the HA from influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA from an A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5) influenza virus;
(b) the stem domain of the HA from influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2) and the globular head domain of the HA from an influenza virus of the H5 subtype;
(c) the stem domain of the HA from influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2) and the globular head domain of the HA from an influenza virus of the H7 subtype;
(d) the stem domain of the HA from influenza virus B/Malaysia/2506/2004, B/Florida/4/2006, B/Wisconsin/1/2010, or B/Brisbane/60/2008 and the globular head domain of the HA from an influenza virus of the H5 subtype;
(e) the stem domain of the HA from influenza virus B/Malaysia/2506/2004, B/Florida/4/2006, B/Wisconsin/1/2010, or B/Brisbane/60/2008 and the globular head domain of the HA from an influenza virus of the H7 subtype;
or
(f) the stem domain of the HA from influenza virus B/Malaysia/2506/2004, B/Florida/4/2006, B/Wisconsin/1/2010, or B/Brisbane/60/2008 and the globular head domain of the HA from a different strain of influenza B virus.

4 more elements

An immunogenic composition comprising:

A (i) a first chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises the stem domain of the HA of influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA of influenza virus /Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
and
(ii) a second chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises (a) the stem domain of the HA of influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2);
and (b) the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
or
B (i) a first chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises the stem domain of the HA of influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
and
(ii) a second chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises (a) the stem domain of the HA of influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2);
and (b) the globular head domain of the HA of influenza virus B/Malaysia/2506/2004 and the globular head domain of the HA of influenza virus A/Netherlands/219/03 (H7), A/Canada/504/04 (H7), A/Canada/444/04 (H7), A/chicken/Jalisco/CPA1/2012 (H7), A/mallard/Alberta/24/2001 (H7), A/Rhea/NC/39482/93 (H7), or A/mallard/Netherlands/12/2000 (H7).

6 more elements

An immunogenic composition comprising:

A (i) a first virus comprising a genome engineered to express a first nucleic acid that encodes a chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises the stem domain of the HA of influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
and
(ii) a second virus comprising a genome engineered to express a second nucleic acid that encodes a chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises (a) the stem domain of the HA of influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2);
and (b) the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
or
B (i) a first virus comprising a genome engineered to express a first nucleic acid that encodes a chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises the stem domain of the HA of influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
and
(ii) a second virus comprising a genome engineered to express a second nucleic acid that encodes a chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises (a) the stem domain of the HA of influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2);
and (b) the globular head domain of the HA of influenza virus B/Malaysia/2506/2004 and the globular head domain of the HA of A/Netherlands/219/03 (H7), A/Canada/504/04 (H7), A/Canada/444/04 (H7), A/chicken/Jalisco/CPA1/2012 (H7), A/mallard/Alberta/24/2001 (H7), A/Rhea/NC/39482/93 (H7), or A/mallard/Netherlands/12/2000 (H7).

6 more elements

An immunogenic composition comprising:

A (i) a first virus comprising a first chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises the stem domain of the HA of influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
and
(ii) a second virus comprising a second chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises (a) the stem domain of the HA of influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2);
and (b) the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
or
B (i) a first virus comprising a first chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises the stem domain of the HA of influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA of influenza virus A/Vietnam/1203/2004 (H5), A/Indonesia/5/2005 (H5), A/Anhui/1/2005 (H5), A/Bar headed goose/Quinghai/1A/2005 (H5), A/turkey/Turkey/1/2005 (H5), or A/Whooperswan/Mongolia/244/2005 (H5);
and
(ii) a second virus comprising a second chimeric influenza virus hemagglutinin (HA) polypeptide, wherein the polypeptide comprises (a) the stem domain of the HA of influenza virus A/Victoria/361/2011 (H3N2), A/harbor seal/Massachusetts/1/2011 (H3N8), or A/Indiana/10/2011 (H3N2);
and (b) the globular head domain of the HA of influenza virus A/Netherlands/219/03 (H7), A/Canada/504/04 (H7), A/Canada/444/04 (H7), A/chicken/Jalisco/CPA1/2012 (H7), A/mallard/Alberta/24/2001 (H7), A/Rhea/NC/39482/93 (H7), or A/mallard/Netherlands/12/2000 (H7).

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/109,358Filed 17 Dec 2013 · us provisional application
Priority: 18 Dec 2012
Published: US 2014/0328875 A16 Nov 2014
Granted: 21 Jun 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 39/145
Viral antigens: orthomyxoviridae, e.g. influenza virus
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61P 31/16
For RNA viruses: for influenza or rhinoviruses
C07K 14/005
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from viruses

Family

Application61/738,672Us provisional application · filed 18 Dec 2012
Application61/840,899Us provisional application · filed 28 Jun 2013
US 2014/0328875 A1Pre-grant publication · published 6 Nov 2014
US 9,371,366 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

patentgrep

Loading patent…

Abstract

Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.

Facts

Application

14/109,358Filed 17 Dec 2013 · us provisional application

Priority

18 Dec 2012

Published

US 2014/0328875 A16 Nov 2014

Granted

21 Jun 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 39/145
Viral antigens: orthomyxoviridae, e.g. influenza virus
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61P 31/16
For RNA viruses: for influenza or rhinoviruses
C07K 14/005
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from viruses