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US 9,371,350 B2Granted
Trehalose derivatives and pharmaceutical compositions for treating neurodegenerative diseases
AssigneePostech Foundation
InventorsSung-Kee Chung, Woo Sirl Lee, Boram Kim, Jungkyun Im, Subhash C. Ghosh
Life of this patent
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Abstract
The invented inositol and trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tissues and utilized for the treatment of neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.
Claims3
A trehalose compound of Formula (3) or a salt thereof:
- wherein,
- R is
- n being an integer in the range of 1 to 12;
- and
- R1 is hydrogen, R, alkyl or —COR′, R′ being hydrogen, alkyl, aminoalkyl, arylalkyl, cycloalkyl, heteroalkyl or a phosphor.
2 more elements
Dependencies are inferred from the claim text.