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US 9,371,264 B2Granted
Treprostinil derivative compounds and methods of using same
AssigneeCorsair Pharma, Inc.
InventorsCyrus K. Becker, Jürg R. Pfister, Gwenaella Rescourio, Meenakshi S. Venkatraman, Xiaoming Zhang
Life of this patent
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Abstract
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
Claims9
A compound according to Formula (IA)
- wherein,
- Z is —OH, —OR11, or P1;
- R11 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, haloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, alkylcycloalkyl, substituted alkylcycloalkyl, alkylcycloheteroalkyl, or substituted alkylcycloheteroalkyl,
- P1 is selected from the group consisting of:
- wherein,
- m is 1, 2, 3, or 4;
- R14 and R15 are independently in each occurrence selected from the group consisting of H, cycloalkyl, alkylcycloalkyl, haloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, substituted aryl, substituted heteroaryl, substituted arylalkyl, and substituted heteroarylalkyl;
- or
- R14 and R15 taken together with the atoms to which they attach optionally form a 5- to 7-membered ring;
- and,
- R1 and R2 are independently H or P2, wherein at least one of R1 and R2 is P2, wherein
- P2 is selected from the group consisting of:
- wherein,
- R14 is selected from the group consisting of H, cycloalkyl, alkylcycloalkyl, haloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, substituted aryl, substituted heteroaryl, substituted arylalkyl, and substituted heteroarylalkyl;
- or an enantiomer or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.