# US 9,370,460 B2 · Systems and methods for treating amblyopia by visual stimulation of the brain > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,370,460 B2 - Document ID: US9370460B2 - Status: Granted - Kind: B2 - Application number: 14/427,888 - Filed: 2013-09-15 - Published: 2015-10-29 - Granted: 2016-06-21 - Earliest claimed: 2012-09-14 - Assignees: Visior Technologies, LTD - Applicants: Visior Technologies, LTD - Inventors: Ilan Vadai; Yuval Avni - Web page: https://patentgrep.com/patent/US9370460B2 ## CPC - A61H 5/00: Exercisers for the eyes - A61B 3/032: Devices for presenting test symbols or characters, e.g. test chart projectors (A61B3/036 takes precedence) - A61B 3/08: for testing binocular or stereoscopic vision, e.g. strabismus - A61B 3/085: {for testing strabismus} - A61H 5/005: {Exercisers for training the stereoscopic view} - G02B 27/017: {Head mounted} - A61H 2201/1604: Head - A61H 2201/165: Wearable interfaces - A61H 2201/5007: computer controlled - A61H 2201/5015: using specific interfaces or standards, e.g. USB, serial, parallel - A61H 2201/5097: wireless - A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS ## Abstract A system for treating amblyopia through the visual stimulation of the brain through a predetermined regime is provided. The system for treating amblyopia comprises a headmountable visual content display device, a controller unit, a visual content source, a data storage device, a graphic processing unit and an audio source. A protocol useful for treating amblyopia by visual stimulation of the brain is also provided. A predetermined regime useful for treating amblyopia by stimulation of the brain is additionally provided. ## Claims ### Claim 1 A system useful for treating amblyopia by stimulation configured to increase brain blood flow of a user, comprising: a head mountable visual display device having at least one displaying area and coupled to a controller unit, the controller unit configured to alter presentation of a video image in a streaming video content in real time for presenting the video image to each eye of the user in accordance with a pre-determined stimulation regime; an audio device configured to provide an audio stimulation to each ear of the user according to the pre-determined stimulation regime; the pre-determined stimulation regime further including at least one visibly noticed intensity alteration of an image parameter defining the video image presented on at least one display area of the head mountable visual display device; the controller unit further configured to provide the pre-determined stimulation regime; wherein, the pre-determined stimulation regime applies a modifying step by altering the image parameter at a frequency configured to be in a range of 0.5-60 Hz; and wherein the image parameter is selected from the group consisting of contrast, brightness, sharpness, saturation, resolution, and any combination thereof; and wherein the audio device further provides the audio stimulation according to the pre-determined stimulation regime by differing ear volume administered proximal to a side of the user having a deficient eye from that administered proximal to another side of the user not having the deficient eye. ### Claim 2 (depends on 1) The system of claim 1, wherein the intensity alteration of the image parameter is configured to be in a range of −99% to +99% of the image parameter defining the presented video image. ### Claim 3 (depends on 1) The system of claim 1, wherein the audio device is configured to provide audio stimulation according to said predetermined stimulation regime by elevating ear volume administered proximal to the side of the user having the deficient eye, and by reducing ear volume administered proximal to another side of the user not having the deficient eye. ### Claim 4 (depends on 1) The system of claim 1, wherein said controller unit additionally comprises a data storage device adapted to be operatively connected to said controller unit configured to store said predetermined stimulation regime. ### Claim 5 (depends on 1) The system of claim 1, wherein said controller unit comprises a graphic processing unit configured to alter said at least one display parameter according to said predetermined stimulation regime. ### Claim 6 (depends on 1) The system of claim 1, wherein said at least one display parameter is displayed enhanced to the deficient eye and displayed dampened to the fellow eye. ### Claim 7 (depends on 1) The system of claim 1, wherein said controller unit is additionally configured to insert, based on the pre-determine stimulation regime, at least one overlay object of at least one object on said at least one displaying area. ### Claim 8 (depends on 7) The system of claim 7, wherein said controller unit is additionally configured to trigger audio stimuli associated with at least one overlay object according to said predetermined stimulation regime. ### Claim 9 (depends on 7) The system of claim 7, wherein said controller unit is additionally configured to synchronize audio to the insertion of at least one overlay of at least one object according to said predetermined stimulation regime. ### Claim 10 (depends on 1) The system of claim 1, wherein said controller unit is additionally configured to introduce based on the pre-determined stimulation regime at least one flicker event on said at least one displaying area. ### Claim 11 (depends on 10) The system of claim 10, wherein said controller unit is additionally configured to insert the at least one flicker event displayed to the deficient eye, wherein the flicker event occurs by displaying a sequence of frames that are not part of original frames in the video. ### Claim 12 A process useful for treating amblyopia by stimulation configured to increase brain blood flow of a user comprising: placing a head mountable visual display device on a user, the device having at least one displaying area and coupled to a controller unit, the controller unit configured to alter presentation of a video image in a streaming video content in real time for presenting the video image to each eye of the user in accordance with a pre-determined stimulation regime; having an audio device operatively connected to the head mountable visual display, the audio device configured to provide an audio stimulation to each ear of the user according to the pre-determined stimulation regime; having the pre-determined stimulation regime further including at least one visibly noticed intensity alteration of an image parameter defining the video image presented on at least one display area of the head mountable visual display device; having the controller unit further configured to provide the pre-determined stimulation regime; wherein, the pre-determined stimulation regime applies a modifying step by altering the image parameter at a frequency configured to be in a range of 0.5-60 Hz; and wherein the image parameter is selected from the group consisting of contrast, brightness, sharpness, saturation, resolution, and any combination thereof; and wherein the pre-determined stimulation regime is affecting properties of the audio stimulation in conjunction to the modifying step of the image parameter; and wherein the audio device further provides the audio stimulation according to the pre-determined stimulation regime by differing ear volume administered proximal to a side of the user having a deficient eye from that administered proximal to another side of the user not having the deficient eye. ### Claim 13 (depends on 12) The process of claim 12, wherein said visual display device is configured to display in a dichoptic presentation selected from the group consisting of Side by Side, Frame Sequential, and Field Sequential presentation. ### Claim 14 A predetermined regime useful for increasing the cerebral blood flow in the visual system of an amblyopic patient comprising modifying at least one displaying area by changing a display parameter affecting display presentation at the frequency configured to be in the range of 0.5-60 Hz; altering at least one visibly noticed intensity of the display parameter defining a video image presented on at least one display area of a head mountable visual display device; selecting the display parameter from the group consisting of contrast, brightness, sharpness, saturation, resolution, and any combination thereof; and wherein the pre-determined visual stimulation regimen is affecting properties of audio stimulation in conjunction to the modifying step of the display parameter; and wherein an audio device further providing the audio stimulation according to the pre-determined stimulation regime by differing ear volume administered proximal to a side of the user having a deficient eye from that administered proximal to another side of the user not having the deficient eye; and wherein said modification is configured to increase the cerebral blood flow in the visual system in comparison to a regime lacking said modifications. ### Claim 15 (depends on 14) The regime of claim 14, wherein said predetermined stimulation regime additionally comprises introducing at least one flicker event. ### Claim 16 (depends on 14) The regime of claim 14, wherein said predetermined stimulation regime additionally comprises triggering an audio stimulation configured to be administered to at least one ear by elevating ear volume administered proximal to the side of the user having the deficient eye, and by reducing ear volume administered proximal to another side of the user not having the deficient eye. ### Claim 17 (depends on 14) The regime of claim 14, wherein said predetermined stimulation regime is additionally configured to insert at least one overlay of at least one object on a video content displayed on said at least one displaying area. ### Claim 18 (depends on 14) The regime of claim 14, wherein said modifying step is configured to alter the level of said at least one display parameter within a range of 99% to +99% of an intensity of said at least one display parameter of a streamed video content. ### Claim 19 (depends on 14) The regime of claim 14, wherein said predetermined stimulation regime additionally comprises triggering an audio stimulation configured to be administered to at least one ear; and wherein said predetermined stimulation regime is additionally configured to insert at least one overlay of at least one object on said video content displayed on said at least one displayed area; and wherein said step of inserting said at least one overlay of said at least one object is configured to be coherently connected to said triggering of said audio stimulation. ### Claim 20 (depends on 14) The regime of claim 14, wherein said predetermined stimulation regime is configured to operate in real time. ### Claim 21 A visual stimulation regime for a binocular image display device comprising providing at least one visibly noticeable intensity alteration of at least one display parameter to at least one display area; said intensity alteration of said display parameter is applied to said at least one display area in a range of −99% to +99% of said intensity of said display parameter; providing an audio device configured to provide an audio stimulation to each ear of a user according to the pre-determined stimulation regime; the pre-determined stimulation regime further including at least one visibly noticed intensity alteration an image parameter defining the video image presented on at least one display area of the head mountable visual display device; the controller unit further configured to provide the pre-determined stimulation regime; wherein, the pre-determined stimulation regime applies a modifying step by altering the image parameter at a frequency configured to be in a range of 0.5-60 Hz; and wherein the image parameter is selected from the group consisting of contrast, brightness, sharpness, saturation, resolution, and any combination thereof; and wherein the audio device further provides the audio stimulation according to the pre-determined stimulation regime by differing ear volume administered proximal to a side of the user having a deficient eye from that administered proximal to another side of the user not having the deficient eye. ### Claim 22 (depends on 21) The regime of claim 21, wherein said predetermined stimulation regime additionally comprises at least one visibly noticeable intensity alteration of at least one value of at least one image parameter defining a video image as presented on the at least one display area; said intensity alteration of said image parameter values is configured to be in the range of −99% to +99% of said intensity of said image parameter defining the presented video image. ### Claim 23 A visual stimulation regime for an image display device comprises providing at least one visibly noticeable intensity alteration of at an image parameter defining a video image as presented on at least one display area; said intensity alteration of said image parameter is configured to be in a range of −99% to +99% of said intensity of said image parameter, wherein said image parameter is selected from the group consisting of contrast, brightness, sharpness, saturation, resolution or other conventional parameters and any combination thereof; providing an audio device configured to provide an audio stimulation to each ear of a user according to the pre-determined stimulation regime; the pre-determined stimulation regime further including at least one visibly noticed intensity alteration said image parameter defining the video image presented on at least one display area of the head mountable visual display device; the controller unit further configured to provide the pre-determined stimulation regime; wherein, the pre-determined stimulation regime applies a modifying step by altering said image parameter at a frequency configured to be in a range of 0.5-60 Hz; and wherein said image parameter is selected from the group consisting of contrast, brightness, sharpness, saturation, resolution, and any combination thereof; and wherein the audio device further provides the audio stimulation according to the pre-determined stimulation regime by differing ear volume administered proximal to a side of the user having a deficient eye from that administered proximal to another side of the user not having the deficient eye.