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US 9,365,508 B2Granted
Aroyl thiourea derivatives
AssigneesUniversity Court of the University of St Andrews, University Court of the University of Dundee
InventorsSonia Lain, Nicholas James Westwood, David Philip Lane
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Abstract
The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar′ are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.
Claims14
A compound according to formula (I):
- wherein:
- X is O and Y is S;
- —Z— is —C(O)—;
- Ar is 1,4-phenylene;
- each of —R1 and —R2 is —H, and —R3 is an amino-substituted, saturated, straight chain C3-C10 alkyl group;
- and
- Ar′— is a moiety of formula (II)
- wherein:
- each T1, T2, and T3 is a carbon atom, where each R6 is independently selected from the group consisting of hydrogen, O1-6 alkyl, halo, C1-6 alkoxy, alkylthio, alkylamino and dialkylamino;
- each R7 is independently selected from the group consisting of hydrogen, halo, nitro, cyano, carboxy, formyl or C(═O)OR4, C(═S)OR4, C(═O)SR4, C(═S)SR4, C(═O)NH2 and C(═S)NH2 w herein (i) one or both hydrogen atoms of C(═O)NH2 and C(═S)NH2 may be independently exchanged for R4, C(O)R4, S(O)R4, S(O)2R4 and SO2OR4, and (ii) at least one R7 is not hydrogen;
- and
- R8 is selected from the group consisting of alkyl, alkoxy, alkylthio, OH, SH, halo, NHC(═O)R4, NHC(═S)R4 or NH2 wherein one or both hydrogen atoms of the NH2 may be independently exchanged for R4, OC(═O)R4, OC(═S)R4, SC(═O)R4, or SC(═S)R4,
- each R4 is independently selected from the group consisting of alkyl and aryl,
- or a physiologically acceptable salt or solvate thereof.
11 more elements
Dependencies are inferred from the claim text.