Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof
AssigneeFraunhofer USA, Inc.
InventorsAlexei Prokhnevsky, Vidadi Yusibov
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Abstract
The present invention relates to novel virus-like particles (VLPs) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus. The target polypeptide may be antigenic or therapeutic. The first and the second plant enveloped viruses may be the same. Either plant enveloped virus may be a plant rhabdovirus. Also provided are methods of making and using the VLPs.
Claims22
A virus-like particle comprising a matrix protein from a first plant enveloped virus and a surface polypeptide, wherein the first plant enveloped virus is a plant rhabdovirus, and wherein the surface polypeptide comprises
- (a) a surface exposed portion from a target polypeptide wherein the target polypeptide is a polypeptide not from the first plant enveloped virus,
- (b) a transmembrane domain, and
- (c) a cytosolic tail from a transmembrane protein of a second plant enveloped virus.
Dependencies are inferred from the claim text.