Chemical engineering processes and apparatus for the synthesis of compounds
AssigneeFull Spectrum Laboratories Limited
InventorsRobert Winnicki, Marc Donsky
Life of this patent
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Abstract
The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
Claims19
An in vitro method for producing
- (a) tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) in different ratios, or
- (b) cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) in different ratios comprising the steps of:
- reacting cannabigerolic acid (CBGA) with a cannabinoid synthase in a reaction mixture;
- selecting the pH of the reaction mixture in a range between about 4.0 and about 8.0 to produce
- (i) tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) when the cannabinoid synthase is tetrahydrocannabinolic acid synthase (THCA synthase), or
- (ii) cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) when the cannabinoid synthase is cannabidiolic acid synthase (CBDA synthase), and
- recovering the THCA and CBCA or CBDA and CBCA so produced.
An ex vivo method for producing the products tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) in different ratios comprising the steps of:
- reacting cannabigerolic acid (CBGA) with tetrahydrocannabinolic acid synthase (THCA synthase) in a reaction mixture;
- modifying the pH of the reaction mixture in a range from about 4.0 and about 8.0 to produce tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) in different ratios;
- and
- recovering the THCA and CBCA so produced.
An ex vivo method for producing the products cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) in different ratios comprising the steps of:
- reacting cannabigerolic acid (CBGA) with cannabidiolic acid synthase (CBDA synthase) in a reaction mixture;
- modifying the pH of the reaction mixture in a range between about 4.0 and about 8.0 to produce cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) in different ratios;
- and
- recovering the CBDA and CBCA so produced.
Dependencies are inferred from the claim text.