Natural product antibiotics and analogs thereof
AssigneesChildren's Medical Center Corporation, President and Fellows of Harvard College
InventorsPaula I. Watnick, Patrick Ymele-Leki, Jon Clardy, Shugeng Cao
Life of this patent
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Abstract
Provided herein are pure and isolated natural products and analogs thereof of Formula (I), (II), (III), and (IV), pharmaceutical compositions thereof, and methods of use, for example, for treating a bacterial infection. Further provided are methods useful in identifying an inhibitor of bacterial sugar fermentation in a bacterial strain, such as a compound (inhibitor) of Formula (I), (II), (III), or (IV): or a pharmaceutically acceptable salt thereof.
Claims7
A method of treating a bacterial infection in a subject comprising administering an effective amount of a compound of Formula (I-b):
- or pharmaceutically acceptable salt thereof, to the subject;
- wherein:
- each occurrence of RA, RB, and RC is hydrogen;
- R3 is unsubstituted C2-C10alkyl,
- wherein the bacterial infection is an Escherichia coli, Pseudomonas aeruginosa, Vibrio cholerae, methicillin-resistant Staphylococcus aureus, or Mycobacterium tuberculosis infection.
Dependencies are inferred from the claim text.