Nanoscale probe structure and application thereof
AssigneeNational Tsing Hua University
InventorsFan-Gang Tseng, Yi-Chuan Chen
Life of this patent
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Abstract
A nanoscale probe structure, including: a first probe having a tip top end and a second probe having a planar top end, wherein a metallic layer coats the on the tip top end, an insulating layer coats around the tip top end of the first probe; and a metallic layer coats on the planar top end, an insulating layer coats around the planar top end of the second probe. The structure of present invention can applied in atomic force microscopy to measure the electricity physiology signal inside and outside the cell membrane, which can limit the measure region to specific little area for the measure of electricity physiology signal and effectively decrease the miscellaneous noise disturbance from other region.
Claims14
A nanoscale probe structure, comprising:
- a first probe having a tip top end;
- and
- a second probe having a planar top end,
- wherein the tip top end is coated with a metallic layer, and the first probe is coated with an insulating layer around the tip top end;
- the planar top end is coated with a metallic layer, and the planar top end is coated with an insulating layer around the planar top end;
- and
- wherein the metallic layer on the first probe or the second probe is a platinum (Pt) metallic layer or a iridium (Ir) metallic layer.
A detector of measuring an electrophysiological signal on membrane channel proteins, comprising:
- a first probe having a tip top end;
- and
- a second probe having a planar top end,
- wherein the tip top end is coated with a metallic layer, and the first probe is coated with a hafnium oxide (HfO2) insulating layer around the tip top end;
- the planar top end is coated with a metallic layer, and the second probe is coated with a hafnium oxide (HfO2) insulating layer around the planar top end;
- and
- wherein the metallic layer on the first probe or the second probe is a platinum (Pt) metallic layer or a iridium (Ir) metallic layer.
A method of measuring an electrophysiological signal on membrane channel proteins, comprising:
- providing a first probe having a tip top end, wherein the tip top end is coated with a metallic layer, and the first probe is coated with a hafnium oxide (HfO2) insulating layer around the tip top end;
- providing a second probe having a planar top end, wherein the planar top end is coated with a metallic layer, and the second probe is coated with a hafnium oxide (HfO2) insulating layer around the planar top end;
- loading a micro-droplet having a liposome on the planar top end;
- entering the tip top end into the liposome;
- and
- closing the tip top end and the planar top end to each other to measure an electrophysiological signal on membrane channel proteins embedded in the liposome,
- wherein the metallic layer on the first probe or the second probe is a platinum (Pt) metallic layer or a iridium (Ir) metallic layer.
Dependencies are inferred from the claim text.