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US 9,353,154 B2Granted
Compositions for labeling nerves and methods of use
AssigneeAvelas Biosciences, Inc.
InventorsJesus Gonzalez, Junjie Liu
Life of this patent
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Abstract
The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.
Claims13
A targeting molecule that labels a neuron, nerve, or tissue or external structure associated therewith, consisting essentially of:
- (a) an isolated peptide sequence consisting of Formula (XVII):
- X10-X11-X12-Gly-X13-X14-X15 (Formula (XVII)) (SEQ ID NO:
- 50);
- wherein X10 is selected from:
- Glu, His, Ala, Thr, or Lys;
- wherein X11 is selected from:
- His, Ala, Thr, Lys, or Glu;
- wherein X12 is selected from:
- Ala or Thr;
- wherein X13 is selected from:
- Lys, Cys, or Gly;
- wherein X14 is selected from:
- Gly;
- and
- wherein X15 is selected from:
- Cys;
- and
- (b) a fluorescent moiety;
- wherein the targeting molecule labels the neuron, nerve, or tissue or external structure associated therewith.
16 more elements
Dependencies are inferred from the claim text.