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US 9,353,084 B2Granted
2-amino 3,5,5-trifluoro-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treatment of Alzheimer's disease
AssigneeH. Lundbeck A/S
InventorsKarsten Juhl, Mauro Marigo, Lena Tagmose, Thomas Jensen
Life of this patent
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Abstract
The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the reduction of Aβ deposits is beneficial such as Alzheimer's disease.
Claims22
A compound of formula I
- Ar is selected from the group consisting of phenyl, pyridyl, pyrimidyl, pyrazinyl, imidazolyl, pyrazolyl, 1,2,4-triazolyl, thiophenyl, thiazolyl, oxazolyl, isoxazolyl, 1,3,4-thiadiazolyl, isothiazolyl, 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, furanyl, furazanyl and 1,2,4-thiadiazolyl and where the Ar is optionally substituted with one or more halogen, CN, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 fluoroalkyl or C1-C6 alkoxy;
- R1 is C1-C3 alkyl or C1-C3 fluoroalkyl;
- R2 is hydrogen, halogen, C1-C3 fluoroalkyl or C1-C3 alkyl;
- and
- R3 is C1-C3 alkyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.