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US 9,351,993 B2Granted
Polymeric treatment compositions
AssigneeMicroVention, Inc.
InventorsGregory M. Cruise, Michael J. Constant, Joshua Garretson
Life of this patent
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Abstract
Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
Claims9
A composition comprising:
- a biocompatible polymer comprising:
- a first monomer selected from a group consisting of aminopropyl methacrylamide, aminoethyl methacrylamide, N-(3-methylphridine)acrylamide, N-(2-(4-aminophenyl)ethylacrylamide, N-(4-aminobenzyl)acrylamide, N-(2-4-imidazolyl)ethyl)acrylamide and combinations thereof;
- a second monomer selected from a group consisting of t-butyl acrylate, t-butyl acrylamide, n-octyl methacrylate, methyl methacrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, derivatives thereof or combinations thereof;
- an aqueous solution with a non-physiological pH;
- and
- a visualization agent;
- wherein the visualization agent is an iodinated compound, barium sulfate tantalum, superparamagnetic iron oxide, gadolinium molecules or a combination thereof;
- wherein the biocompatible polymer is soluble in the aqueous solution and insoluble at a physiological pH at a treatment site.
5 more elements
A composition comprising:
- a first aqueous solution at non-physiological pH;
- a polymer comprising:
- a first monomer selected from a group consisting of aminopropyl methacrylamide, aminoethyl methacrylamide, N-(3-methylpyridine)acrylamide, N-(2-(4-aminophenyl)ethylacrylamide, N-(4-aminobenzyl)acrylamide, N-(2-4-imidazolyl)ethyl)acrylamide and combinations thereof;
- a second monomer selected from a group consisting of t-butyl acrylate, t-butyl acrylamide, n-octyl methacrylate, methyl methacrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, derivatives thereof or combinations thereof;
- wherein the polymer has a concentration of from about 1% to 35% w/w, that is soluble in the first aqueous solution at non-physiological pH and insoluble in a second aqueous solution at physiological pH;
- and
- a particulate visualization agent at a concentration of from about 20% w/w to about 60% w/w, wherein the visualization agent is an iodinated compound, barium sulfate, tantalum, superparamagnetic iron oxide, gadolinium molecules or a combination thereof.
4 more elements
Dependencies are inferred from the claim text.