US 9,349,178 B1 · Synthetic data-driven hemodynamic determination in medical imaging

Abstract

In hemodynamic determination in medical imaging, the classifier is trained from synthetic data rather than relying on training data from other patients. A computer model (in silico) may be perturbed in many different ways to generate many different examples. The flow is calculated for each resulting example. A bench model (in vitro) may similarly be altered in many different ways. The flow is measured for each resulting example. The machine-learnt classifier uses features from medical scan data for a particular patient to estimate the blood flow based on mapping of features to flow learned from the synthetic data. Perturbations or alterations may account for therapy so that the machine-trained classifier may estimate the results of therapeutically altering a patient-specific input feature. Uncertainty may be handled by training the classifier to predict a distribution of possibilities given uncertain input distribution. Combinations of one or more of uncertainty, use of synthetic training data, and therapy prediction may be provided.

Claims21

Dependent claims

A method for hemodynamic determination in medical imaging, the method comprising:

acquiring medical scan data representing a vessel structure of a patient;
extracting a set of features from the medical scan data;
modifying a first of the features of the set, the modifying representing a change to the vessel structure due to therapy;
assigning an uncertainty to the first feature of the set;
inputting, by a processor, the features to a machine-trained classifier, the features including the first feature after the modifying and with the uncertainty, the machine trained classifier trained only from synthetic data not specific to any patients;
and
outputting, by the processor with application of the machine-trained classifier, a hemodynamic metric with a confidence interval for different values of the hemodynamic metric.

4 more elements

Dependencies are inferred from the claim text.

Synthetic data-driven hemodynamic determination in medical imaging

Life of this patent

Synthetic data-driven hemodynamic determination in medical imaging

Life of this patent

Abstract

Claims21