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AssigneesDublin City University, Amic AB
InventorsAnthony Joseph Killard, Magdalena Maria Dudek, Brian MacCraith, Ib Mendel-Hartvig, Ove Öhman
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The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.
A lateral capillary flow device for monitoring and/or measurement of coagulation in a liquid sample wherein the device is an open lateral flow device which comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a fibrinogen or thrombin clotting agent or a derivative thereof is deposited on at least part of the defined flow path zone to accelerate coagulation of the liquid sample, to enable formation of an evenly distributed clot along the defined flow path zone and to result in a change in flow rate or cessation of flow of the liquid sample along the defined flow path zone, wherein the surface area to volume ratio between the sample and defined flow path of the device is improved or increased such that the flow path zone comprises a planar surface with a plurality of regularly spaced projections which induce capillary action in the liquid sample along the defined flow path, wherein said regularly spaced projections extend along substantially the entire length of the flow path zone,
A lateral capillary flow device for monitoring and/or measurement of coagulation in a liquid sample wherein the device is an open lateral flow device which comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a fibrinogen or thrombin clotting agent or a derivative thereof is deposited on at least part of the defined flow path zone to accelerate coagulation of the liquid sample, to enable formation of an evenly distributed clot along the defined flow path zone and to result in a change in flow rate or cessation of flow of the liquid sample along the defined flow path zone, wherein the surface area to volume ratio between the sample and defined flow path of the device is improved or increased such that the flow path zone comprises a planar surface with a plurality of regularly spaced projections which induce capillary action in the liquid sample along the defined flow path, wherein said regularly spaced projections extend along substantially the entire length of the flow path zone wherein the clotting agent is deposited on the entire surface of the defined flow path zone.
A lateral capillary flow device for monitoring and/or measurement of coagulation in a liquid sample wherein the device is an open lateral flow device which comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a fibrinogen or thrombin clotting agent or a derivative thereof is deposited on at least part of the defined flow path zone to accelerate coagulation of the liquid sample, to enable formation of an evenly distributed clot along the defined flow path zone and to result in a change in flow rate or cessation of flow of the liquid sample along the defined flow path zone, wherein the surface area to volume ratio between the sample and defined flow path of the device is improved or increased such that the flow path zone comprises a planar surface with a plurality of regularly spaced projections which induce capillary action in the liquid sample along the defined flow path, wherein said regularly spaced projections extend along substantially the entire length of the flow path zone wherein the clotting agent also comprises a supporting reagent material selected from poly(ethylene glycol) (PEG), sugars, non-ionic surfactants, and combinations thereof.
Dependencies are inferred from the claim text.