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US 9,346,866 B2Granted
Inhibition of tace activity with cyclic peptides
AssigneeThe Regents of the University of California
InventorsMichael E. Selsted, Dat Q. Tran
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Abstract
A method is provided for inhibiting TACE activity in a human subject, through the administration of a θ-defensin, analog, or derivative. Such a θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The θ-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.
Claims7
A method of treating rheumatoid arthritis in an animal, comprising:
- determining that the animal has rheumatoid arthritis, and
- administering a pharmacologically acceptable formulation of a θ-defensin to the animal in an amount effective to inhibit TACE activity.
Dependencies are inferred from the claim text.