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US 9,346,780 B2Granted
Process for producing dihydro-2H-pyran derivatives
AssigneeOkinawa Institute of Science and Technology School Corporation
InventorsPandurang V. Chouthaiwale, Fujie Tanaka
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Abstract
Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.
Claims4
A compound of formula II:
- wherein
- R1 is alkyl, cycloalkyl, aryl, heterocycloalkyl or heteroaryl, which is optionally substituted with one or more substituent selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxyl, mono- or polyhalo alkyl, mono- or polyhalo alkoxy and phenyl;
- R2 is alkyl or benzyl;
- and
- R4 is hydroxyl or halogen;
- or racemate, enantiomer, diastereomer, mixture thereof, or pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.