Nanofibrous conduits for nerve regeneration
AssigneeUniversity of Washington
InventorsMiqin Zhang, Narayan Bhattarai
Life of this patent
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Abstract
A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration.
Claims19
A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end capable of coapting the conduit to a first end of a severed nerve and a second end capable of coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) nanofibers, wherein the chitosan-poly(caprolactone) nanofibers comprise about 20 to about 80 percent by weight chitosan and about 80 to about 20 percent by weight poly(caprolactone), and wherein the chitosan-poly(caprolactone) nanofibers are a miscible polymer blend prepared from a chitosan-poly(caprolactone) solution that is suitable for electrospinning.
A chitosan-poly(caprolactone) nanofiber comprising from about 20 to about 80 percent by weight chitosan and from about 80 to about 20 percent by weight poly(caprolactone), wherein the chitosan-poly(caprolactone) nanofiber is a miscible polymer blend prepared from a chitosan-poly(caprolactone) solution that is suitable for electrospinning.
Dependencies are inferred from the claim text.