Spontaneously immortalized avian cell line
AssigneeThe United States of America as represented by the Secretary of Agriculture
InventorHuanmin Zhang
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Abstract
Embodiments of the present invention relate to a spontaneously immortalized avian cell line, designated ZS-1. Immortalized avian cell line, ZS-1 is derived from primary chicken embryo fibroblasts (CEF). The ZS-1 cell line is free of endogenous retroviruses, including Avian Leukosis Viruses (ALV), and particularly ALV sub-group E. Moreover, the ZS-1 cell line susceptible to all subgroups of ALV, including subgroup E. Cells of the ZS-1 cell line and sub-clones thereof may be used for inter alia the production of viral agents, including recombinant viral agents, expression of recombinant proteins, and diagnostic assays.
Claims9
An immortal cell line ZS-1 having Accession Number ATTC PTA-121623, wherein the cell line ZS-1 is derived from primary Chicken Embryo Fibroblasts (CEF) from the virus free chicken line, 0.TVB*S1, wherein the immortal cell line ZS-1 is free of avian leukosis virus (ALV) and supports virus replication.
Dependencies are inferred from the claim text.