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AssigneesNorth Carolina State University, Northwestern University
InventorsTodd R. Klaenhammer, Erika Pfeiler, Mansour Mohamadzadeh
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Methods and compositions for treating or preventing inflammatory disorders are provided. The compositions of the invention comprise a recombinant bacterium genetically modified to decrease the display of lipoteichoic acid on the cell surface. Methods of the invention comprise administering to a subject a recombinant bacterium modified to decrease the display of lipoteichoic acid on the cell surface. Administration of the recombinant bacterium promotes a desired therapeutic response. The recombinant bacterium may be administered in a single dose or series of doses. Methods of the invention find use in treating or preventing a variety of inflammatory disorders including, for example, treating or preventing inflammatory bowel disease, colitis, or Crohn's disease.
A recombinant or isolated bacterium having been genetically modified to decrease the display of lipoteichoic acid (LTA) on the surface of said bacterium, wherein the genetic modification comprises deletion or substitution of at least one base pair such that the expression of at least one polynucleotide encoding a phosphoglycerol transferase is decreased,
A method of making a recombinant or isolated bacterium, said method comprising genetically modifying a bacterium to decrease the display of lipoteichoic acid (LTA) on the surface of said bacterium,
Dependencies are inferred from the claim text.