Cardiovascular disease treatment and prevention

A method, comprising:

• administering, to the skin of a subject having or at risk of hypertension, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) and an effective amount of molecular nitric oxide to treat or prevent hypertension, and a carrier having a phosphatidylcholine component entrapping the molecular nitric oxide, wherein the molecular nitric oxide is present within the carrier as a gas or bound by hydrogen bonds or van der Waals forces.

A method, comprising contacting the skin of a subject having or at risk for atherosclerosis and/or hypertension with a composition comprising:

• an emulsion comprising a first phase comprising thyrotropin-releasing hormone (TRH), molecular nitric oxide, and lecithin, and a second phase comprising an emulsifier, wherein the lecithin is present at least about 0.25% by weight of the composition, wherein the first phase comprises no more than about 250 ppm of water by weight of the composition, and wherein the molecular nitric oxide is present within the emulsion as a gas or bound by hydrogen bonds or van der Waals forces to the lecithin.

A method, comprising:

• administering, to the skin of a subject having or at risk of a cardiovascular disease, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) and an effective amount of molecular nitric oxide to treat or prevent the cardiovascular disease, and a carrier having a phosphatidylcholine component entrapping the molecular nitric oxide, wherein the molecular nitric oxide is present within the carrier as a gas or bound by hydrogen bonds or van der Waals forces.

A method, comprising contacting the skin of a subject having or at risk of a cardiovascular disease with a composition comprising:

• an emulsion comprising a first phase comprising thyrotropin-releasing hormone (TRH), molecular nitric oxide and lecithin, and a second phase comprising an emulsifier, wherein the lecithin is present at at least about 0.25% by weight of the composition, wherein the first phase comprises no more than about 250 ppm of water by weight of the composition, and wherein the molecular nitric oxide is present within the emulsion as a gas or bound by hydrogen bonds or van der Waals forces to the lecithin.

A method, comprising:

• administering, topically to the skin of a subject, a composition comprising an emulsion comprising a first phase comprising an effective amount of thyrotropin-releasing hormone (TRH), molecular nitric oxide and phosphatidylcholine to treat or prevent atherosclerosis in the subject, and a second phase comprising an emulsifier, wherein the composition comprises no more than about 250 ppm of water by weight of the composition.

A method, comprising:

• administering, topically to the skin of a subject, a composition comprising an emulsion comprising a first phase comprising an effective amount of thyrotropin-releasing hormone (TRH), molecular nitric oxide and phosphatidylcholine to treat or prevent hypertension in the subject, and a second phase comprising an emulsifier, wherein the composition comprises no more than about 250 ppm of water by weight of the composition.