Bispecific antibodies

A bispecific antibody produced by a method comprising culturing a host cell or host cells comprising nucleic acid or nucleic acids encoding a bispecific antibody, wherein the bispecific antibody comprises:

• a first antibody H chain comprising a variable region comprising CDRs 1, 2, and 3 that comprise SEQ ID NOs:
• 105-107, respectively;
• a second antibody H chain comprising a variable region comprising CDRs 1, 2, and 3 that comprise SEQ ID NOs:
• 126-128, respectively;
• and
• identical first and second antibody L chains, each L chain comprising a variable region comprising CDRs 1, 2, and 3 that comprise SEQ ID NOs:
• 156-158, respectively.

A bispecific antibody produced by a method comprising culturing a host cell or host cells comprising nucleic acid or nucleic acids encoding a bispecific antibody, wherein the bispecific antibody comprises:

• a first antibody H chain comprising a variable region comprising CDRs 1, 2, and 3 that consist of SEQ ID NOs:
• 105-107, respectively;
• a second antibody H chain comprising a variable region comprising CDRs 1, 2, and 3 that consist of SEQ ID NOs:
• 126-128, respectively;
• and
• identical first and second antibody L chains, each L chain comprising a variable region comprising CDRs 1, 2, and 3 that consist of SEQ ID NOs:
• 156-158, respectively.

A bispecific antibody that specifically binds to blood coagulation factor IX and/or activated blood coagulation factor IX, and specifically binds to blood coagulation factor X, wherein the bispecific antibody comprises:

• a first antibody H chain comprising a variable region comprising SEQ ID NO:
• 45;
• a second antibody H chain comprising a variable region comprising SEQ ID NO:
• 52;
• and
• identical first and second antibody L chains, each comprising a variable region comprising SEQ ID NO:
• 62.

A bispecific antibody produced by a method comprising culturing a host cell or host cells comprising a nucleic acid or nucleic acids encoding a bispecific antibody, wherein the bispecific antibody comprises:

• a first antibody H chain comprising a variable region comprising SEQ ID NO:
• 45;
• a second antibody H chain comprising a variable region comprising SEQ ID NO:
• 52;
• and
• identical first and second antibody L chains, each comprising a variable region comprising SEQ ID NO:
• 62.

A bispecific antibody that specifically binds to blood coagulation factor IX and/or activated blood coagulation factor IX, and specifically binds to blood coagulation factor X, wherein the bispecific antibody comprises:

• a first antibody H chain comprising SEQ ID NO:
• 20;
• a second antibody H chain comprising SEQ ID NO:
• 25;
• and
• identical first and second antibody L chains, each comprising SEQ ID NO:
• 32.

A bispecific antibody produced by a method comprising culturing a host cell or host cells comprising nucleic acid or nucleic acids encoding a bispecific antibody comprising:

• a first antibody H chain comprising SEQ ID NO:
• 20;
• a second antibody H chain comprising SEQ ID NO:
• 25;
• and
• identical first and second antibody L chains, each comprising SEQ ID NO:
• 32.