Cephem compound having catechol or pseudo-catechol structure

A compound of the formula:

• or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof,
• wherein
• W is —CH2—, —S— or —O—;
• a) U is —CH2—, —S—, —S(═O)— or —O— when W is —CH2—;
• or
• b) U is —CH2— when W is —S— or —O—;
• L is —CH2—, —CH═CH—, —CH2—CH═CH— or —CH═CH—CH2—;
• R1 is a substituted or unsubstituted carbocyclic group or a substituted or unsubstituted heterocyclic group;
• with regard to R2A and R2B,
• a) R2A is a hydrogen atom, a substituted or unsubstituted amino group, —SO3H, a substituted or unsubstituted amino sulfonyl group, carboxyl group, a substituted or unsubstituted (lower alkyl)oxycarbonyl group, a substituted or unsubstituted carbamoyl group, hydroxyl group, or a substituted carbonyloxy group;
• and R2B is a hydrogen atom, or
• b) R2A and R2B are taken together to form a substituted or unsubstituted methylidene group or a substituted or unsubstituted hydroxyimino group;
• R3 is a hydrogen atom, —OCH3 or —NH—CH(═O);
• R11 is
• E is a group selected from the following formulae which are substituted or unsubstituted on the ring:
• wherein the bond to the quaternary nitrogen atom binds to L, and the other bond binds to R10;
• p is an integer from 1 to 3;
• n is an integer of 1 or 2;
• RX is an optionally substituted lower alkyl group;
• R10 is R12 or a group represented by the formula:
• wherein ring A is a benzene ring, or a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms;
• k is an integer from 2 to 5;
• each R4 is independently a hydrogen atom, halogen, hydroxyl group, —CN, —C(═O)—R5, —C(═O)—OH, —C(═O)—OR5, or —OR5;
• R5 is a lower alkyl group or halo(lower)alkyl group;
• and
• G is a single bond, a substituted or unsubstituted lower alkylene group, a substituted or unsubstituted alkenylene group or a substituted or unsubstituted alkynylene group;
• B is a single bond or a 5- or 6-membered heterocyclic group containing at least 1-3 nitrogen atoms;
• D is a single bond, —C(═O)—, —O—C(═O)—, —C(═O)—O—, —NR6—, —NR6—C(═O)—, —C(═O)—NR6—, —NR6—C(═O)—NR6—, —O—, —S—, —S(═O)—, —S(═O)2—NR6—, —NR6—S(═O)2—, —NR6—CH2—, —CH2—NR6— or —S(═O)2—;
• each R6 is independently a hydrogen atom or a substituted or unsubstituted lower alkyl group;
• R12 is a hydrogen atom, halogen, hydroxyl group, —SO3H, a substituted or unsubstituted amino group, a substituted or unsubstituted carboxyl group, a substituted or unsubstituted carbamoyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted amino sulfonyl group, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group, a substituted or unsubstituted lower alkynyl group, a substituted or unsubstituted non-aromatic carbocyclic group or a substituted or unsubstituted non-aromatic heterocyclic group.