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US 9,334,263 B2Granted
Compositions useful for treating disorders related to kit
AssigneeBlueprint Medicines Corporation
InventorsBrian L. Hodous, Joseph L. Kim, Chandrasekhar V. Miduturu, Douglas Wilson, Yulian Zhang
Life of this patent
Estimating the term…
Abstract
Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.
Claims21
A compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ring A is selected from monocyclic or bicyclic aryl, monocyclic or bicyclic heteroaryl, cycloalkyl and heterocyclyl;
- each X and Y is independently selected from CR1 and N;
- Z is selected from C1-C6 alkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, and monocyclic or bicyclic heterocyclylalkyl;
- wherein each of C1-C6 alkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, and monocyclic or bicyclic heterocyclylalkyl is substituted with 0-5 independent occurrences of RC;
- L is selected from a bond, —(C(R2)(R2))m—, —(C2-C6 alkynylene)-, —(C2-C6 alkenylene)-, —(C1-C6 haloalkylene)-, —(C1-C6 heteroalkylene)-, —(C1-C6 hydroxyalkylene)-, —C(O)—, —O—, —S—, —S(O), —SO2—, —N(R2)—, —O—(C1-C6 alkylene)-, —(C1-C6 alkylene)-O—, —N(R2)—CO—, —CO—N(R2)—, —(C1-C6 alkylene)-N(R2)—, —N(R2)—(C1-C6 alkylene)-, —N(R2)—CO—(C1-C6 alkylene)-, —CO—N(R2)—(C1-C6 alkylene)-, —N(R2)—SO2—, —SO2—N(R2)—, —N(R2)—SO2—(C1-C6 alkylene)-, and —SO2—N(R2)—(C1-C6 alkylene)-;
- each RA and RB is independently selected from C1-C6 alkyl, halo, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 heteroalkyl, monocyclic or bicyclic aralkyl, —N(R2)(R2), cyano, and —OR2;
- each RC is independently selected from C1-C6 alkyl, C1-C6 alkynyl, halo, C1-C6 heteroalkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 hydroxyalkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aryloxy, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heterocyclyl, monocyclic or bicyclic heterocyclylalkyl, nitro, cyano, —C(O)R2, —OC(O)R2, —C(O)OR2, —SR2, —S(O)2R2, —S(O)2—N(R2)(R2), —(C1-C6 alkylene)-S(O)2—N(R2)(R2), —N(R2)(R2), —C(O)—N(R2)(R2), —N(R2)(R2)—C(O)R2, —(C1-C6 alkylene)-N(R2)—C(O)R2, —NR2S(O)2R2, —P(O)(R2)(R2), and —OR2;
- wherein each of heteroalkyl, haloalkyl, haloalkoxy, alkyl, alkynyl, cycloalkyl, aryl, aryloxy, aralkyl, heterocyclyl, and heterocyclylalkyl is substituted with 0-5 occurrences of Ra;
- or 2 RC together with the carbon atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring substituted with 0-5 occurrences of Ra;
- each R1 is independently selected from hydrogen, C1-C6 alkyl, monocyclic aralkyl, C1-C6 hydroxyalkyl, halo, C1-C6 haloalkyl, —N(R2)(R2), and —OR2;
- each R2 is independently selected from hydrogen, hydroxyl, halo, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl;
- wherein each of C1-C6 alkyl, cycloalkyl and heterocyclyl is substituted with 0-5 occurrences of Rb, or 2 R2 together with the carbon or nitrogen atom to which they are attached form a cycloalkyl or heterocyclyl ring;
- each Ra and Rb is independently selected from halo, hydroxyl, —C(O)R′, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 heteroalkyl, C1-C6 hydroxyalkyl, —NR′R′, and cycloalkyl;
- wherein cycloalkyl is substituted with 0-5 occurrences of R′;
- R′ is hydrogen, hydroxyl, or C1-C6 alkyl;
- and
- m, p, and q are each independently 0, 1, 2, 3, or 4.
15 more elements
Dependencies are inferred from the claim text.