Fluidically integrated magnetic bead beater

A system for at least one of homogenization and lysis of a sample comprising:

• one or more walls forming an enclosed chamber having an inlet and one or more fluidic connections configured to introduce at least the sample into the chamber;
• a permanent magnet having a positive pole and a negative pole and disposed within the chamber;
• a magnet guide configured to laterally guide the permanent magnet between a first position and a second position, and to maintain a substantially constant orientation of the positive pole and the negative pole of the permanent magnet during the movement;
• and
• one or more magnets disposed outside the chamber,
• wherein movement of the one or more magnets changes a magnetic field between the one or more magnets and the permanent magnet, and wherein the permanent magnet is configured to laterally move between the first and second positions in response to the changing magnetic field, and wherein the permanent magnet is configured to excite a plurality of beads disposed within the chamber when the permanent magnet moves laterally between the first and second positions.